FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation (Q29616127)

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30 December 2019

review article

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title

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation (English)

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30 December 2019

1

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30 December 2019

author name string

Bruce E Clurman

series ordinal

2

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language of work or name

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publication date

1 February 2008

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30 December 2019

published in

Nature Reviews Cancer

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30 December 2019

volume

8

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30 December 2019

page(s)

83-93

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issue

2

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Ubiquitin: Roles in protein modification and breakdown

30 December 2019

cites work

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Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase

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SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities

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F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

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A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p

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Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast

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Degradation of the transcription factor Gcn4 requires the kinase Pho85 and the SCF(CDC4) ubiquitin-ligase complex

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Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis.

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The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast

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Regulation of the G1 phase of the cell cycle by periodic stabilization and degradation of the p25rum1 CDK inhibitor

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Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

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Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

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The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

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SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

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Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

31 March 2020

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Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10

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Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

31 March 2020

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Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

31 March 2020

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Expression of mouse Fbxw7 isoforms is regulated in a cell cycle- or p53-dependent manner.

31 March 2020

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hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53.

31 March 2020

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Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

31 March 2020

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SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

31 March 2020

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Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

31 March 2020

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Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases

31 March 2020

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Fbw7/hCDC4 dimerization regulates its substrate interactions

31 March 2020

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Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination

31 March 2020

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Fbw7 isoform interaction contributes to cyclin E proteolysis.

31 March 2020

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Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination

31 March 2020

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A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size

31 March 2020

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Two F-box/WD-repeat proteins Pop1 and Pop2 form hetero- and homo-complexes together with cullin-1 in the fission yeast SCF (Skp1-Cullin-1-F-box) ubiquitin ligase.

31 March 2020

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Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle

31 March 2020

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Association of human cyclin E with a periodic G1-S phase protein kinase

31 March 2020

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Cyclin E in normal and neoplastic cell cycles

31 March 2020

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Kinase-independent function of cyclin E

31 March 2020

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Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation

31 March 2020

1 reference

Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation

31 March 2020

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Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase

31 March 2020

1 reference

The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability

31 March 2020

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Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms

31 March 2020

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The Myc/Max/Mad network and the transcriptional control of cell behavior

31 March 2020

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Myc degradation: dancing with ubiquitin ligases.

31 March 2020

1 reference

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

31 March 2020

1 reference

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

31 March 2020

1 reference

Activation by c-Myc of transcription by RNA polymerases I, II and III.

31 March 2020

1 reference

c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

31 March 2020

1 reference

The ubiquitin-specific protease USP28 is required for MYC stability

31 March 2020

1 reference

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

31 March 2020

1 reference

A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

31 March 2020

1 reference

AP-1 as a regulator of cell life and death

31 March 2020

1 reference

The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling

31 March 2020

1 reference

c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors

31 March 2020

1 reference

Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases

31 March 2020

1 reference

The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase.

31 March 2020

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SREBP in signal transduction: cholesterol metabolism and beyond

31 March 2020

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Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7).

31 March 2020

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Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding.

31 March 2020

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Notch signaling: cell fate control and signal integration in development

31 March 2020

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31 March 2020

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FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

31 March 2020

1 reference

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

31 March 2020

1 reference

Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice

31 March 2020

1 reference

c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

31 March 2020

1 reference

NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

31 March 2020

1 reference

Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc

31 March 2020

1 reference

Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin

31 March 2020

1 reference

SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production

31 March 2020

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31 March 2020

The renaissance of GSK3

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PI3K/Akt signalling pathway and cancer.

31 March 2020

1 reference

Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.

31 March 2020

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Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein

31 March 2020

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DNA copy number losses in human neoplasms

31 March 2020

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Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

31 March 2020

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Mutational analysis of the hCDC4 gene in gastric carcinomas

31 March 2020

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CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability.

31 March 2020

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Cyclin E dysregulation and chromosomal instability in endometrial cancer.

31 March 2020

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CDC4 gene expression as potential biomarker for targeted therapy in prostate cancer.

31 March 2020

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BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets

31 March 2020

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FBXW7/hCDC4 is a general tumor suppressor in human cancer.

31 March 2020

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Mutation analysis of hCDC4 in AML cells identifies a new intronic polymorphism

31 March 2020

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Somatic mutation of hCDC4 gene is rare in lung adenocarcinomas.

31 March 2020

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Infrequent mutations of Archipelago (hAGO, hCDC4, Fbw7) in primary ovarian cancer

31 March 2020

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Low frequency of hCDC4 mutations in human primary ovarian cancer.

31 March 2020

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hCDC4 variation in osteosarcoma

31 March 2020

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Inactivation of hCDC4 can cause chromosomal instability

31 March 2020

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The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling.

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

31 March 2020

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FBXW7/hCDC4 controls glioma cell proliferation in vitro and is a prognostic marker for survival in glioblastoma patients

31 March 2020

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The FBXW7 beta-form is suppressed in human glioma cells

31 March 2020

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Ras activity regulates cyclin E degradation by the Fbw7 pathway.

31 March 2020

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The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4.

31 March 2020

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Induction of mammary gland hyperplasia and carcinomas in transgenic mice expressing human cyclin E

31 March 2020

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Deregulated cyclin E induces chromosome instability

31 March 2020

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Mutation of hCDC4 leads to cell cycle deregulation of cyclin E in cancer.

31 March 2020

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p53 and p21 form an inducible barrier that protects cells against cyclin E-cdk2 deregulation

31 March 2020

1 reference

A mouse model for cyclin E-dependent genetic instability and tumorigenesis.

31 March 2020

1 reference

Deregulated cyclin E promotes p53 loss of heterozygosity and tumorigenesis in the mouse mammary gland

31 March 2020

1 reference

p53 and SCFFbw7 cooperatively restrain cyclin E-associated genome instability.

31 March 2020

1 reference

Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide

31 March 2020

1 reference

Sustained loss of a neoplastic phenotype by brief inactivation of MYC

31 March 2020

1 reference

Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia

31 March 2020

1 reference

Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex

31 March 2020

1 reference

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

31 March 2020

1 reference

Systematic analysis and nomenclature of mammalian F-box proteins

31 March 2020

1 reference

A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin

31 March 2020

1 reference

The SCFCdc4 ubiquitin ligase regulates calcineurin signaling through degradation of phosphorylated Rcn1, an inhibitor of calcineurin

31 March 2020

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18094723

31 March 2020

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30 April 2017

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30 December 2019

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Consolidated OpenCitations Corpus – April 2017

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