Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1 (Q24304533)

9

object named as

Gregg L Semenza

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author name string

Weibo Luo

1

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Hongxia Hu

2

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Ryan Chang

3

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Jun Zhong

4

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Matthew Knabel

5

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Robert O'Meally

6

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Robert N Cole

Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL

7

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language of work or name

English

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publication date

27 May 2011

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published in

Cell

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volume

145

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page(s)

732-44

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issue

5

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cites work

1 reference

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HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

19 March 2017

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HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

19 March 2017

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

19 March 2017

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Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1

19 March 2017

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

19 March 2017

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Targeting HIF-1 for cancer therapy

19 March 2017

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Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis

19 March 2017

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Why do cancers have high aerobic glycolysis?

19 March 2017

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Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

19 March 2017

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Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

19 March 2017

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An essential role for p300/CBP in the cellular response to hypoxia

19 March 2017

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

19 March 2017

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Hypoxia--a key regulatory factor in tumour growth

7 April 2017

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Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

7 April 2017

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Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

7 April 2017

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Hypoxia. 2. Hypoxia regulates cellular metabolism

7 April 2017

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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

27 September 2017

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Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha

27 September 2017

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Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

27 September 2017

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Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth

27 September 2017

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27 September 2017

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Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for

27 September 2017

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Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

27 September 2017

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The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing

27 September 2017

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Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene

27 September 2017

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Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

30 May 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21620138

12 December 2020

inferred from PubMed ID database lookup

Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21620138

12 December 2020

inferred from PubMed ID database lookup

RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.03.054

7 January 2021

Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.03.054

7 January 2021

Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.03.054

7 January 2021

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.03.054

7 January 2021

10.1016/J.CELL.2011.03.054

Identifiers

DOI

1 reference

2160628

2160628

1 reference

1 reference

1 reference