Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends (Q24306412)

DNA ligase 4

1 reference

X-ray repair cross complementing 4

1 reference

X-ray repair cross complementing 6

1 reference

Non-homologous end joining factor 1

1 reference

X-ray repair cross complementing 5

1 reference

Martin D Burkhalter

3

1 reference

ORCID Public Data File 2021

author name string

Steven A Roberts

1

0 references

Natasha Strande

2

0 references

Christina Strom

4

0 references

Jody M Havener

5

0 references

Paul Hasty

6

0 references

Dale A Ramsden

Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro

7

0 references

language of work or name

English

0 references

publication date

22 April 2010

0 references

published in

Nature

0 references

volume

464

0 references

issue

7292

0 references

page(s)

1214-7

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859099

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859099

DNA polymerase beta is the major dRP lyase involved in repair of oxidative base lesions in DNA by mammalian cell extracts

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859099

Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859099

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859099

MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859099

Distinct roles of XRCC4 and Ku80 in non-homologous end-joining of endonuclease- and ionizing radiation-induced DNA double-strand breaks

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859099

Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859099

Dependence of antibody gene diversification on uracil excision.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859099

Oxidative Strand Scission of Nucleic Acids: Routes Initiated by Hydrogen Abstraction from the Sugar Moiety

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859099

The lyase activity of the DNA repair protein beta-polymerase protects from DNA-damage-induced cytotoxicity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859099

Double-strand break repair in Ku86- and XRCC4-deficient cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859099

Identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase gamma and its role in mitochondrial base excision repair in vitro

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859099

Functional analysis of the amino-terminal 8-kDa domain of DNA polymerase beta as revealed by site-directed mutagenesis. DNA binding and 5'-deoxyribose phosphate lyase activities

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859099

The complexity of DNA damage: relevance to biological consequences

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859099

Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859099

Studies on mammalian mutants defective in rejoining double-strand breaks in DNA.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859099

The nuclear serine/threonine protein kinase DNA-PK

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859099

Evidence that base stacking potential in annealed 3' overhangs determines polymerase utilization in yeast nonhomologous end joining

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859099

Ku antigen interacts with abasic sites

30 May 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE08926

Deleting Ku70 is milder than deleting Ku80 in p53-mutant mice and cells.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859099

Attempted base excision repair of ionizing radiation damage in human lymphoblastoid cells produces lethal and mutagenic double strand breaks

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2859099

DNA Double-strand Breaks Generated by the Repair of X-ray Damage in Chinese Hamster Cells

29 November 2018

1 reference

12 December 2020

Biochemical properties of Saccharomyces cerevisiae DNA polymerase IV

1 reference

12 December 2020

Two-lesion kinetic model of double-strand break rejoining and cell killing

1 reference

12 December 2020

Human DNA polymerase beta deoxyribose phosphate lyase. Substrate specificity and catalytic mechanism

1 reference

12 December 2020

Evidence for an imino intermediate in the DNA polymerase beta deoxyribose phosphate excision reaction

1 reference

12 December 2020

A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining

1 reference

https://api.crossref.org/works/10.1038%2FNATURE08926

7 January 2021

Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1038%2FNATURE08926

7 January 2021

End-bridging is required for pol mu to efficiently promote repair of noncomplementary ends by nonhomologous end joining

1 reference

https://api.crossref.org/works/10.1038%2FNATURE08926

7 January 2021

Selective extraction of polyoma DNA from infected mouse cell cultures

1 reference

https://api.crossref.org/works/10.1038%2FNATURE08926

7 January 2021