Protein kinase, DNA-activated, catalytic subunit (Q21105070)

Armadillo-type fold

1 reference

Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily

1 reference

Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family

1 reference

DNA-dependent protein kinase catalytic subunit, catalytic domain, protein family

1 reference

PIK-related kinase, FAT family

1 reference

NUC194 domain, protein family

1 reference

PIK-related kinase family

1 reference

FATC domain, protein family

1 reference

Phosphatidylinositol 3/4-kinase, conserved site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

2 references

DNA-dependent protein kinase activity

transcription factor binding

1 reference

8 April 2019

A role of DNA-PK for the metabolic gene regulation in response to insulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

protein serine/threonine kinase activity

IPI

4 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527

31 October 2017

DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527

31 October 2017

A role of DNA-PK for the metabolic gene regulation in response to insulin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527

21 references

8 April 2019

DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

Functional interaction of BRCA1/ATM-associated BAAT1 with the DNA-PK catalytic subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

Enhancer activation requires trans-recruitment of a mega transcription factor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

Regulation of DNA-dependent protein kinase by protein kinase CK2 in human glioblastoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

A role for the HOXB7 homeodomain protein in DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

Aire's partners in the molecular control of immunological tolerance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

The role of insulin-like growth factor binding protein-3 in the breast cancer cell response to DNA-damaging agents

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

A role of DNA-PK for the metabolic gene regulation in response to insulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

2 references

protein kinase activity

3 references

8 April 2019

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

protein domain specific binding

1 reference

8 April 2019

Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

protein serine/threonine kinase activity

IPI

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

A role of DNA-PK for the metabolic gene regulation in response to insulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

1 reference

31 October 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527

transcription regulator complex

1 reference

8 April 2019

A role of DNA-PK for the metabolic gene regulation in response to insulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

DNA-dependent protein kinase-DNA ligase 4 complex

1 reference

8 April 2019

Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

1 reference

31 October 2017

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527

4 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527

31 October 2017

Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527

1 reference

8 April 2019

Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

1 reference

8 April 2019

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

protein-containing complex

HDA

1 reference

8 April 2019

Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

response to ionizing radiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

negative regulation of response to gamma radiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

positive regulation of immune system process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

positive regulation of developmental growth

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

T cell differentiation in thymus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

1 reference

8 April 2019

The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

positive regulation of fibroblast proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

lymphocyte differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

T cell receptor V(D)J recombination

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

negative regulation of apoptotic process

1 reference

8 April 2019

DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

double-strand break repair via alternative nonhomologous end joining

1 reference

8 April 2019

The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

negative regulation of immunoglobulin production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

regulation of smooth muscle cell proliferation

1 reference

8 April 2019

DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

cellular response to DNA damage stimulus

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

pro-B cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

B cell lineage commitment

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

protein destabilization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

intrinsic apoptotic signaling pathway in response to DNA damage

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

cellular response to insulin stimulus

1 reference

8 April 2019

A role of DNA-PK for the metabolic gene regulation in response to insulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

positive regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

ectopic germ cell programmed cell death

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

immunoglobulin V(D)J recombination

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527

cell population proliferation

1 reference

1 January 2018

The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78527&geneProductId=UniProtKB:P78527

response to gamma radiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

positive regulation of type I interferon production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

T cell lineage commitment

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

A role of DNA-PK for the metabolic gene regulation in response to insulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

negative regulation of cellular senescence

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

immunoglobulin production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

2 references

protein ubiquitination

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling

TAS

protein phosphorylation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

activation of innate immune response

1 reference

8 April 2019

HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

immune system process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

innate immune response

1 reference

8 April 2019

double-strand break repair

3 references

8 April 2019

The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

regulation of epithelial cell proliferation

IBA

1 reference

8 April 2019

The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

cellular response to DNA damage stimulus

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

positive regulation of double-strand break repair via nonhomologous end joining

IBA

1 reference

8 April 2019

Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78527

http://purl.uniprot.org/uniprot/P78527

exact match

1 reference

1 reference

FATC domain

1 reference

PIK-related kinase, FAT

1 reference

NUC194

1 reference

Phosphatidylinositol 3/4-kinase, conserved site

1 reference

Phosphatidylinositol 3-/4-kinase, catalytic domain

1 reference

DNA-dependent protein kinase catalytic subunit, catalytic domain

1 reference