The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53 (Q24307855)

negative regulation of DNA damage response, signal transduction by p53 class mediator

GOA release 2020-03-11

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GOA release 2020-03-11

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Hiroaki Higashitsuji

1

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Hisako Higashitsuji

2

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Katsuhiko Itoh

3

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Toshiharu Sakurai

4

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Toshikazu Nagao

5

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Yasuhiko Sumitomo

6

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Haruhiko Sumitomo

7

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Tomoko Masuda

8

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Simon Dawson

9

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Yutaka Shimada

10

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R John Mayer

11

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Jun Fujita

Sequential changes in hepatocarcinogenesis induced by diethylnitrosamine plus thioacetamide in Fischer 344 rats: induction of gankyrin expression in liver fibrosis, pRB degradation in cirrhosis, and methylation of p16(INK4A) exon 1 in hepatocellular

12

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language of work or name

English

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publication date

July 2005

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published in

Cancer Cell

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volume

8

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issue

1

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page(s)

75-87

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cites work

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Ubiquitin-mediated proteolysis: biological regulation via destruction

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Yin Yang 1 is a negative regulator of p53.

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Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

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A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

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Apoptosis: a link between cancer genetics and chemotherapy

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Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

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Tumor necrosis factor: an apoptosis JuNKie?

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Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

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Transferring substrates to the 26S proteasome.

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The p53-Mdm2 module and the ubiquitin system.

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p53 has a direct apoptogenic role at the mitochondria

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A novel protein overexpressed in hepatoma accelerates export of NF-kappa B from the nucleus and inhibits p53-dependent apoptosis

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Novel insights into the INK4-CDK4/6-Rb pathway: counter action of gankyrin against INK4 proteins regulates the CDK4-mediated phosphorylation of Rb

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Surfing the p53 network

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Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas

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The ubiquitin ligase COP1 is a critical negative regulator of p53

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Regulation of cellular response to oncogenic and oxidative stress by Seladin-1

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Live or let die: the cell's response to p53

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Inhibiting the p53-MDM2 interaction: an important target for cancer therapy

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Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation

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Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo.

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Control of apoptosis by p53.

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Regulating the p53 system through ubiquitination

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7 January 2021

A post-ubiquitination role for MDM2 and hHR23A in the p53 degradation pathway

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7 January 2021

YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress.

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7 January 2021

Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization

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7 January 2021

U box proteins as a new family of ubiquitin-protein ligases

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7 January 2021

Gankyrin is an ankyrin-repeat oncoprotein that interacts with CDK4 kinase and the S6 ATPase of the 26 S proteasome

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MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity

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7 January 2021

The crystal structure of gankyrin, an oncoprotein found in complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase regulator, and the tumor suppressors Rb and p53

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7 January 2021

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

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7 January 2021

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

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7 January 2021

Genetic changes and histopathological grades in human hepatocellular carcinomas

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7 January 2021

Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

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7 January 2021

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

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7 January 2021

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

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7 January 2021

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

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7 January 2021

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

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7 January 2021

Critical role for a central part of Mdm2 in the ubiquitylation of p53.

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7 January 2021

Critical contribution of the MDM2 acidic domain to p53 ubiquitination

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7 January 2021

Regulation of p53 and MDM2 activity by MTBP.

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7 January 2021

Mechanisms underlying ubiquitination

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7 January 2021

Cul4A physically associates with MDM2 and participates in the proteolysis of p53.

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https://api.crossref.org/works/10.1016%2FJ.CCR.2005.06.006

7 January 2021