Regulating the p53 system through ubiquitination (Q35691573)

9 August 2017

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title

Regulating the p53 system through ubiquitination (English)

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9 August 2017

protein ubiquitination

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Yili Yang

1

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9 August 2017

Chou-Chi H Li

series ordinal

2

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9 August 2017

Allan M Weissman

series ordinal

3

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9 August 2017

language of work or name

English

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publication date

1 March 2004

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9 August 2017

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9 August 2017

23

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9 August 2017

2096-2106

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9 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1207411

9 August 2017

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cites work

Post-translational modification of p53 protein in response to ionizing radiation analyzed by mass spectrometry

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Pharmacological rescue of mutant p53 conformation and function

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

MEKK1/JNK signaling stabilizes and activates p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

A matter of life and death

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Mutual dependence of MDM2 and MDMX in their functional inactivation of p53

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Mdm2 promotes the rapid degradation of p53

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

AIS is an oncogene amplified in squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Activation of p53 in cervical carcinoma cells by small molecules.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

p73 is a simian [correction of human] p53-related protein that can induce apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

The tumour suppressor protein p53 can repress transcription of cyclin B.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Regulation of p53 stability by Mdm2

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Phosphorylation of p53 serine 15 increases interaction with CBP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Cancer. p53, guardian of the genome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Acetylation of p53 inhibits its ubiquitination by Mdm2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Regulation of HDM2 activity by the ribosomal protein L11

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

p53-dependent induction of apoptosis by proteasome inhibitors

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Tumor suppression by Ink4a-Arf: progress and puzzles

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Negative control of p53 by Sir2alpha promotes cell survival under stress

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

The p53 stabilizing compound CP-31398 induces apoptosis by activating the intrinsic Bax/mitochondrial/caspase-9 pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Mutations in the p53 gene occur in diverse human tumour types

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Rescue of mutant p53 transcription function by ellipticine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Identification and characterization of the cytoplasmic protein TRAF4 as a p53-regulated proapoptotic gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Drosophila p53 preserves genomic stability by regulating cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

p53: a frequent target for genetic abnormalities in lung cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Live or let die: the cell's response to p53

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

p53 Activation by nitric oxide involves down-regulation of Mdm2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Cocompartmentalization of p53 and Mdm2 is a major determinant for Mdm2-mediated degradation of p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207411

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207411

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9 August 2017

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