GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals (Q24310380)

positive regulation of NLRP3 inflammasome complex assembly

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NLR family, pyrin domain containing 3

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Guanylate binding protein 5

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1

Avinash R Shenoy

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author name string

David A Wellington

2

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Pradeep Kumar

3

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Hilina Kassa

4

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Carmen J Booth

5

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Peter Cresswell

6

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John D MacMicking

https://api.crossref.org/works/10.1126/SCIENCE.1217141

7

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language of work or name

English

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publication date

27 April 2012

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published in

Science

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volume

336

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issue

6080

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page(s)

481-5

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A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection

20 April 2017

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https://api.crossref.org/works/10.1126/SCIENCE.1217141

ASC, which is composed of a PYD and a CARD, is up-regulated by inflammation and apoptosis in human neutrophils

20 April 2017

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https://api.crossref.org/works/10.1126/SCIENCE.1217141

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

20 April 2017

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https://api.crossref.org/works/10.1126/SCIENCE.1217141

Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions

20 April 2017

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https://api.crossref.org/works/10.1126/SCIENCE.1217141

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

20 April 2017

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https://api.crossref.org/works/10.1126/SCIENCE.1217141

Cryopyrin activates the inflammasome in response to toxins and ATP

20 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1217141

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

20 April 2017

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https://api.crossref.org/works/10.1126/SCIENCE.1217141

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf

20 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1217141

A role for mitochondria in NLRP3 inflammasome activation

20 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1217141

How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP

20 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1217141

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

20 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1217141

Non-canonical inflammasome activation targets caspase-11

20 April 2017

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https://api.crossref.org/works/10.1126/SCIENCE.1217141

Gout-associated uric acid crystals activate the NALP3 inflammasome

20 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1217141

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

20 April 2017

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https://api.crossref.org/works/10.1126/SCIENCE.1217141

MUSCLE: a multiple sequence alignment method with reduced time and space complexity

20 April 2017

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https://api.crossref.org/works/10.1126/SCIENCE.1217141

MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0

20 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1217141

Triphosphate structure of guanylate-binding protein 1 and implications for nucleotide binding and GTPase mechanism

20 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1217141

Mutational analysis of the Mycobacterium tuberculosis Rv1625c adenylyl cyclase: residues that confer nucleotide specificity contribute to dimerization

20 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1217141

Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria

20 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1217141

Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

20 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1217141

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

20 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1217141

The inflammasome NLRs in immunity, inflammation, and associated diseases

20 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1217141

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

20 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1217141

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

20 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1217141

7 January 2021

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1217141

7 January 2021

Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1217141

7 January 2021

Site-directed mutagenesis using a single mutagenic oligonucleotide and DpnI digestion of template DNA.

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https://api.crossref.org/works/10.1126%2FSCIENCE.1217141

7 January 2021

Assembly, purification, and assay of the activity of the ASC pyroptosome

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1217141

7 January 2021

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1217141

7 January 2021

Roles of caspase-1 in Listeria infection in mice

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https://api.crossref.org/works/10.1126%2FSCIENCE.1217141

7 January 2021

Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47

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https://api.crossref.org/works/10.1126%2FSCIENCE.1217141

7 January 2021

Immune response in mice that lack the interferon-gamma receptor

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https://api.crossref.org/works/10.1126%2FSCIENCE.1217141

7 January 2021

Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1217141

7 January 2021

Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1217141

7 January 2021

Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1217141

7 January 2021

Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1217141

7 January 2021