Identification of cholesterol-regulating genes by targeted RNAi screening (Q24311691)

GOA release 2020-03-11

cholesterol homeostasis

1 reference

GOA release 2020-03-11

Rainer Pepperkok

10

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Holger Erfle

8

object named as

Holger Erfle

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Martina U Muckenthaler

9

object named as

Martina Muckenthaler

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author name string

Fabian Bartz

1

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Luise Kern

2

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Dorothee Erz

3

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Mingang Zhu

4

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Daniel Gilbert

5

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Till Meinhof

6

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Ute Wirkner

7

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Heiko Runz

Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis

11

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language of work or name

English

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publication date

July 2009

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published in

Cell Metabolism

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volume

10

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issue

1

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page(s)

63-75

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cites work

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Protein sensors for membrane sterols

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An RNAi screening platform to identify secretion machinery in mammalian cells

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A microscope-based screening platform for large-scale functional protein analysis in intact cells

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Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes

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Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles

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Role of cholesterol and lipid organization in disease

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The epithelial-specific adaptor AP1B mediates post-endocytic recycling to the basolateral membrane.

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Cohort studies and the genetics of complex disease

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High-throughput RNAi screening by time-lapse imaging of live human cells

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Reverse transfection on cell arrays for high content screening microscopy.

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Cellular cholesterol trafficking and compartmentalization

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Sterols regulate ER-export dynamics of secretory cargo protein ts-O45-G.

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NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

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Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex

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Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

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Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity

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Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes

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Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip

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Group C Niemann-Pick disease: faulty regulation of low-density lipoprotein uptake and cholesterol storage in cultured fibroblasts

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Novel interaction partners of the TPR/MET tyrosine kinase

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LRP6 mutation in a family with early coronary disease and metabolic risk factors

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Identification of HE1 as the second gene of Niemann-Pick C disease

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Cholesterol sensing, trafficking, and esterification.

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Plasma total homocysteine, B vitamins, and risk of coronary atherosclerosis.

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Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance

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