Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging (Q24311723)

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2 February 2020

title

Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging (English)

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2 February 2020

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GOA release 2020-03-11

regulation of developmental process

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GOA release 2020-03-11

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9

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2 February 2020

Rukshana Shroff

7

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ORCID Public Data File 2021

author name string

Cassandra D Ragnauth

1

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2 February 2020

Derek T Warren

2

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2 February 2020

Yiwen Liu

3

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2 February 2020

Rosamund McNair

4

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2 February 2020

Tamara Tajsic

5

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2 February 2020

Nichola Figg

6

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2 February 2020

Jeremy Skepper

8

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2 February 2020

language of work or name

English

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publication date

10 May 2010

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2 February 2020

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2 February 2020

volume

121

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2 February 2020

issue

20

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2 February 2020

page(s)

2200-2210

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A homozygous ZMPSTE24 null mutation in combination with a heterozygous mutation in the LMNA gene causes Hutchinson-Gilford progeria syndrome (HGPS): insights into the pathophysiology of HGPS

2 February 2020

cites work

1 reference

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7 January 2021

Alterations in intranuclear localization of Runx2 affect biological activity

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7 January 2021

Induction and rejoining of radiation-induced DNA single-strand breaks: "tail moment" as a function of position in the cell cycle

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7 January 2021

Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation.

1 reference

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7 January 2021

Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis.

1 reference

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7 January 2021

Smooth muscle cell depletion and collagen types in progeric arteries

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7 January 2021

Histological and ultrastructural features of atherosclerosis in progeria

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7 January 2021

Death through a tragedy: mitotic catastrophe

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7 January 2021

A progeroid syndrome in mice is caused by defects in A-type lamins

1 reference

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7 January 2021

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

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7 January 2021

Genomic instability in laminopathy-based premature aging

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7 January 2021

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

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7 January 2021

The nuclear lamina comes of age.

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7 January 2021

Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases.

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7 January 2021

Phenotype and course of Hutchinson-Gilford progeria syndrome

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7 January 2021

Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome

1 reference

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7 January 2021

Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice

1 reference

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7 January 2021

Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes

1 reference

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7 January 2021

Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

1 reference

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7 January 2021

Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody

1 reference

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7 January 2021

Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome

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7 January 2021

A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells

1 reference

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7 January 2021

Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging

1 reference

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7 January 2021

A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model

1 reference

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7 January 2021

Vascular smooth muscle polyploidization as a biomarker for aging and its impact on differential gene expression

1 reference

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7 January 2021

Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cells

1 reference

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7 January 2021

A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies

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7 January 2021

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

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7 January 2021

Lamin a truncation in Hutchinson-Gilford progeria.

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7 January 2021

A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.

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7 January 2021

Lamin A-dependent nuclear defects in human aging

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7 January 2021

Compound heterozygous ZMPSTE24 mutations reduce prelamin A processing and result in a severe progeroid phenotype

1 reference

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7 January 2021

Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification

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7 January 2021

7-ketocholesterol induces protein ubiquitination, myelin figure formation, and light chain 3 processing in vascular smooth muscle cells

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7 January 2021

Elevated levels of oxidative DNA damage and DNA repair enzymes in human atherosclerotic plaques

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7 January 2021

Multilineage potential of cells from the artery wall.

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7 January 2021

Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress.

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7 January 2021

Vascular cell senescence: contribution to atherosclerosis

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7 January 2021

A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation.

1 reference

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7 January 2021

The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin

1 reference

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7 January 2021

10.1161/CIRCULATIONAHA.109.902056

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

1549623

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20458013%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1549623

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

1549623