The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose (Q24314582)

Phorbol-12-myristate-13-acetate-induced protein 1

GOA release 2020-03-11

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positive regulation of apoptotic process

GOA release 2020-03-11

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GOA release 2020-03-11

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Xazmin H Lowman

1

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Maureen A McDonnell

2

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Ashley Kosloske

3

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Oludare A Odumade

4

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Christopher Jenness

5

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Christine B Karim

6

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Ronald Jemmerson

7

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Ameeta Kelekar

Extraneuronal roles of cyclin-dependent kinase 5.

8

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language of work or name

English

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publication date

10 December 2010

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published in

Molecular Cell

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volume

40

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issue

5

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page(s)

823-33

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cites work

1 reference

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7 January 2021

The Cdk5 inhibitor roscovitine strongly inhibits glucose uptake in 3T3-L1 adipocytes without altering GLUT4 translocation from internal pools to the cell surface

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7 January 2021

Sequence and structure-based prediction of eukaryotic protein phosphorylation sites

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Chronic effect of fatty acids on insulin release is not through the alteration of glucose metabolism in a pancreatic beta-cell line (beta HC9).

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Glutaminolysis and glycolysis interactions in proliferant cells

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Withdrawal symptoms on display: Bcl-2 members under investigation

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Roscovitine regulates invasive breast cancer cell (MDA-MB231) proliferation and survival through cell cycle regulatory protein cdk5.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Mechanism of CDK5/p25 binding by CDK inhibitors

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7 January 2021

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

1 reference

7 January 2021

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Dual role of proapoptotic BAD in insulin secretion and beta cell survival

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Noxa: at the tip of the balance between life and death.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Autophagy delays apoptotic death in breast cancer cells following DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Crosstalk among Bcl-2 family members in B-CLL: seliciclib acts via the Mcl-1/Noxa axis and gradual exhaustion of Bcl-2 protection.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

The pentose cycle and insulin release in mouse pancreatic islets

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Structural insights into the degradation of Mcl-1 induced by BH3 domains

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

The atypical kinase Cdk5 is activated by insulin, regulates the association between GLUT4 and E-Syt1, and modulates glucose transport in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Catabolism of 2-deoxyglucose by phagocytic leukocytes in the presence of 12-O-tetradecanoyl phorbol-13-acetate

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Integral role of Noxa in p53-mediated apoptotic response

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Understanding the Warburg effect: the metabolic requirements of cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

On the Origin of Cancer Cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Growth factors can influence cell growth and survival through effects on glucose metabolism

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Glucose-induced expression of the cyclin-dependent protein kinase 5 activator p35 involved in Alzheimer's disease regulates insulin gene transcription in pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021

Unique biology of Mcl-1: therapeutic opportunities in cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2010.11.035

7 January 2021