Cellular response to hypoxia involves signaling via Smad proteins (Q24314797)

SMAD family member 4

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Hypoxia inducible factor 1 subunit alpha

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Transforming growth factor beta 2

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SMAD family member 2

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regulation of transforming growth factor beta2 production

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author name string

Hong Zhang

1

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Hasan O Akman

2

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Eric L P Smith

3

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Jin Zhao

4

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Joanne E Murphy-Ullrich

5

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Olcay A Batuman

An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct

6

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language of work or name

English

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publication date

15 March 2003

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published in

Blood

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volume

101

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issue

6

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page(s)

2253-60

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cites work

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7 January 2021

TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis

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Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development

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7 January 2021

Hypoxia-regulated gene expression in fetal wound regeneration and adult wound repair

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7 January 2021

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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7 January 2021

Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors

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7 January 2021

Hypoxia increases thrombospondin-1 transcript and protein in cultured endothelial cells

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7 January 2021

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

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7 January 2021

Thrombospondin-1 is a major activator of TGF-beta1 in vivo

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7 January 2021

Smads: transcriptional activators of TGF-beta responses

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7 January 2021

The functions of thrombospondin-1 and-2.

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7 January 2021

Transforming growth factor-beta: vasculogenesis, angiogenesis, and vessel wall integrity

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7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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7 January 2021

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

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7 January 2021

Ubiquitin-dependent degradation of TGF-beta-activated smad2.

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7 January 2021

Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1

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7 January 2021

Latent transforming growth factor-beta: structural features and mechanisms of activation

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7 January 2021

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

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7 January 2021

Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

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7 January 2021

Transforming growth factor beta2 inhibition of hepatocyte growth factor-induced endothelial proliferation and migration

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7 January 2021

Biomechanical activation of vascular endothelium as a determinant of its functional phenotype.

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7 January 2021

Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations

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7 January 2021

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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7 January 2021

Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium

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7 January 2021

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

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7 January 2021

The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice

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7 January 2021

Regulation of transforming growth factor-beta activation by discrete sequences of thrombospondin 1.

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7 January 2021

Purification and characterization of hypoxia-inducible factor 1

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7 January 2021

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

1 reference

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7 January 2021

Physical and functional interaction of SMADs and p300/CBP

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7 January 2021

Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

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7 January 2021

MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells

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7 January 2021

The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-beta

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7 January 2021

Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression

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7 January 2021

Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane

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7 January 2021

Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism

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7 January 2021

Inhibition of E-selectin gene expression by transforming growth factor beta in endothelial cells involves coactivator integration of Smad and nuclear factor kappaB-mediated signals

1 reference

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7 January 2021

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

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7 January 2021

Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice

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7 January 2021

Detecting and responding to hypoxia

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7 January 2021

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

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7 January 2021

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation

1 reference

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7 January 2021

Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization

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7 January 2021

Antiangiogenic domains shared by thrombospondins and metallospondins, a new family of angiogenic inhibitors

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7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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7 January 2021

Defective angiogenesis in mice lacking endoglin

1 reference

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7 January 2021

Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629

7 January 2021

TGF-beta signal transduction

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7 January 2021

Soluble transforming growth factor-beta type II receptor inhibits negative remodeling, fibroblast transdifferentiation, and intimal lesion formation but not endothelial growth

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629

7 January 2021

Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629

7 January 2021

Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629

7 January 2021

Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629

7 January 2021

Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629

7 January 2021

A murine model of hereditary hemorrhagic telangiectasia

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629

7 January 2021

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629

7 January 2021

Response to hypoxia involves transforming growth factor-beta2 and Smad proteins in human endothelial cells

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629

7 January 2021