A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation (Q24316495)

positive regulation of apoptotic process

GOA release 2020-03-11

1 reference

Secreted frizzled-related protein 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Peter V N Bodine

1

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Barbara Stauffer

2

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Helga Ponce-de-Leon

3

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Ramesh A Bhat

4

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Annamarie Mangine

5

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Laura M Seestaller-Wehr

6

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Robert A Moran

7

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Julia Billiard

8

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Shoichi Fukayama

9

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Barry S Komm

10

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Keith Pitts

11

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Girija Krishnamurthy

12

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Ariamala Gopalsamy

13

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Mengxiao Shi

14

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Jeffrey C Kern

15

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Thomas J Commons

16

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Richard P Woodworth

17

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Matthew A Wilson

18

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Gregory S Welmaker

19

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Eugene J Trybulski

20

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William J Moore

Secreted Frizzled-related proteins: searching for relationships and patterns

21

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language of work or name

English

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publication date

June 2009

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published in

Bone

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volume

44

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issue

6

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page(s)

1063-8

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cites work

1 reference

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Wnt/beta-catenin-pathway as a molecular target for future anti-cancer therapeutics

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The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis

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Structure-function analysis of secreted frizzled-related protein-1 for its Wnt antagonist function

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Secreted frizzled related protein 1 regulates Wnt signaling for BMP2 induced chondrocyte differentiation.

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Expression of secreted frizzled related protein 1, a Wnt antagonist, in brain, kidney, and skeleton is dispensable for normal embryonic development

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Regulatory pathways revealing new approaches to the development of anabolic drugs for osteoporosis

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Reduced relative risk of fractures among users of lithium

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Wnt signaling and osteoblastogenesis

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Lithium use and the risk of fractures.

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Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

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Wnt signaling in osteoblasts and bone diseases

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Regulated expression of sFRP-1 protein by the GeneSwitch system

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A Wnt canon orchestrating osteoblastogenesis

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Pharmacological inhibitors of glycogen synthase kinase 3.

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Molecular bases of the regulation of bone remodeling by the canonical Wnt signaling pathway.

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Wnt signaling: a key regulator of bone mass

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Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes

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Identification of diarylsulfone sulfonamides as secreted frizzled related protein-1 (sFRP-1) inhibitors

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Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides

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Dickkopf-1 is a master regulator of joint remodeling

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Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

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How many drug targets are there?

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WNT and beta-catenin signalling: diseases and therapies

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Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice

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Structural and Kinetic Studies of a Cisplatin-modified DNA Icosamer Binding to HMG1 Domain B

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Disulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modules

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Canonical WNT Signaling Promotes Osteogenesis by Directly StimulatingRunx2Gene Expression

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Regulation of secreted Frizzled-related protein-1 by heparin

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Stimulation of bone formation in vitro and in rodents by statins

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Regulation of bone mass by Wnt signaling

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Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo

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5-Lipoxygenase metabolites inhibit bone formation in vitro

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The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice

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Secreted antagonists of the Wnt signalling pathway

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Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease

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LRP5 and Wnt signaling: a union made for bone

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Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass

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Orally bioavailable GSK-3alpha/beta dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo

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Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

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Small-molecule modulators of Hh and Wnt signaling pathways

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Wnt/beta-catenin signaling pathway as a novel cancer drug target

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Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

19254787

1 reference

Consolidated OpenCitations Corpus – April 2017