Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA (Q24319667)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22573813%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22573813%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

main subject

Thymine DNA glycosylase

1 reference

GOA release 2020-03-11

mismatched DNA binding

1 reference

GOA release 2020-03-11

author

Edwin Pozharski

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22573813%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Atanu Maiti

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22573813%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Alex MacKerell

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22573813%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Alexander C Drohat

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22573813%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

author name string

Muhammad S Noon

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22573813%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

language of work or name

English

0 references

publication date

9 May 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22573813%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

1 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22573813%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

volume

109

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22573813%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

issue

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22573813%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

page(s)

8091-8096

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22573813%20AND%20SRC:MED&resulttype=core&format=json

Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA

1 February 2020

cites work

1 reference

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Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites

19 March 2017

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Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA

19 March 2017

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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

19 March 2017

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Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

19 March 2017

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Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

19 March 2017

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Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects

19 March 2017

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Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions

19 March 2017

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Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase

19 March 2017

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Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase

19 March 2017

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19 March 2017

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Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition

22 April 2017

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Enzymatic capture of an extrahelical thymine in the search for uracil in DNA

19 March 2017

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Electrostatic guidance of glycosyl cation migration along the reaction coordinate of uracil DNA glycosylase

19 March 2017

1 reference

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Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1

19 March 2017

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Mismatch Repair in Methylated DNA: STRUCTURE AND ACTIVITY OF THE MISMATCH-SPECIFIC THYMINE GLYCOSYLASE DOMAIN OF METHYL-CpG-BINDING PROTEIN MBD4

19 March 2017

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Crystal structure of a thwarted mismatch glycosylase DNA repair complex

19 March 2017

1 reference

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All-atom empirical potential for molecular modeling and dynamics studies of proteins

19 March 2017

1 reference

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Scalable molecular dynamics with NAMD

19 March 2017

1 reference

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Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

19 March 2017

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DNA glycosylase recognition and catalysis

19 March 2017

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Dissecting the broad substrate specificity of human 3-methyladenine-DNA glycosylase

19 March 2017

1 reference

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Uracil-DNA glycosylase acts by substrate autocatalysis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361372

The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites

19 March 2017

1 reference

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A new class of uracil-DNA glycosylases related to human thymine-DNA glycosylase

19 March 2017

1 reference

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The CpG dinucleotide and human genetic disease

19 March 2017

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Dependence of substrate binding and catalysis on pH, ionic strength, and temperature for thymine DNA glycosylase: Insights into recognition and processing of G·T mispairs

19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations

19 March 2017

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The curious chemical biology of cytosine: deamination, methylation, and oxidation as modulators of genomic potential.

7 April 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Role of two strictly conserved residues in nucleotide flipping and N-glycosylic bond cleavage by human thymine DNA glycosylase

27 September 2017

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Mutational spectra of human cancer.

27 September 2017

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Transition-state analysis of the DNA repair enzyme MutY.

27 September 2017

1 reference

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Excision of 5-halogenated uracils by human thymine DNA glycosylase. Robust activity for DNA contexts other than CpG.

27 September 2017

1 reference

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Computational approaches for investigating base flipping in oligonucleotides

27 September 2017

1 reference

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Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA.

27 September 2017

1 reference

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Caught in the act: visualization of an intermediate in the DNA base-flipping pathway induced by HhaI methyltransferase

27 September 2017

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Abasic sites in DNA: repair and biological consequences in Saccharomyces cerevisiae

27 September 2017

1 reference

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27 September 2017

1 reference

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Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.

27 September 2017

1 reference

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Thymine-DNA glycosylase and G to A transition mutations at CpG sites

27 September 2017

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Investigation of the mechanisms of DNA binding of the human G/T glycosylase using designed inhibitors

27 September 2017

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Mismatch-specific thymine DNA glycosylase and DNA polymerase beta mediate the correction of G.T mispairs in nuclear extracts from human cells

27 September 2017

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Coordinating the initial steps of base excision repair. Apurinic/apyrimidinic endonuclease 1 actively stimulates thymine DNA glycosylase by disrupting the product complex

27 September 2017

1 reference

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Specificity of human thymine DNA glycosylase depends on N-glycosidic bond stability

30 May 2018

1 reference

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Kinetics of the action of thymine DNA glycosylase

30 May 2018

1 reference

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5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

21 January 2018

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Percentile-based spread: a more accurate way to compare crystallographic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1201010109

Separating substrate recognition from base hydrolysis in human thymine DNA glycosylase by mutational analysis

21 January 2018

1 reference

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Rational Engineering of a DNA Glycosylase Specific for an Unnatural Cytosine:Pyrene Base Pair

21 January 2018

1 reference

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Active-site clashes prevent the human 3-methyladenine DNA glycosylase from improperly removing bases

21 January 2018

1 reference

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Kinetic isotope effect studies of the reaction catalyzed by uracil DNA glycosylase: evidence for an oxocarbenium ion-uracil anion intermediate

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22573813

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

[The effect of nucleotides on oligomeric state of human lactoferrin]

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1201010109

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1073/PNAS.1201010109

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22573813%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

0 references

release_6gfhvtuhujau5hcwjreqwrpewm

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/6gfhvtuhujau5hcwjreqwrpewm

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22573813%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

PubMed publication ID

22573813

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22573813%20AND%20SRC:MED&resulttype=core&format=json