Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair (Q24336569)

8

0 references

Michele Pagano

10

0 references

Anita Saraf

7

0 references

Yasusei Kudo

Yasusei Kudo

6

0 references

Michael P. Washburn

Michael P Washburn

9

0 references

Yeon-Tae Jeong

4

Yeon-Tae Jeong

0 references

Vincenzo D'Angiolella

1

Vincenzo D'Angiolella

0 references

author name string

Valerio Donato

2

0 references

Frances M Forrester

3

0 references

Claudia Pellacani

SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation

5

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language of work or name

English

0 references

publication date

25 May 2012

0 references

published in

Cell

0 references

volume

149

0 references

page(s)

1023-34

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issue

5

0 references

cites work

1 reference

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Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis

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DNA sequence analysis of spontaneous mutagenesis in Saccharomyces cerevisiae

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SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

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Function and regulation of cullin-RING ubiquitin ligases

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Control of chromosome stability by the beta-TrCP-REST-Mad2 axis

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Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion

19 March 2017

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Cyclin F disruption compromises placental development and affects normal cell cycle execution

19 March 2017

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Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis

19 March 2017

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Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits

19 March 2017

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ATR and ATRIP: partners in checkpoint signaling

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A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

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Ribonucleotide reductases

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Hypoxic activation of ATR and the suppression of the initiation of DNA replication through cdc6 degradation

7 April 2017

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Global identification of modular cullin-RING ligase substrates

27 September 2017

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HDM-2 inhibition suppresses expression of ribonucleotide reductase subunit M2, and synergistically enhances gemcitabine-induced cytotoxicity in mantle cell lymphoma

27 September 2017

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Ribonucleotide reductase subunit p53R2 regulates mitochondria homeostasis and function in KB and PC-3 cancer cells

27 September 2017

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Nucleotide deficiency promotes genomic instability in early stages of cancer development

27 September 2017

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53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

27 September 2017

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Identification of early molecular markers for breast cancer

27 September 2017

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Ribonucleotide reductase M2 subunit is a novel diagnostic marker and a potential therapeutic target in bladder cancer

27 September 2017

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Expression of ribonucleotide reductase M2 subunit in gastric cancer and effects of RRM2 inhibition in vitro

27 September 2017

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A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets.

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27 September 2017

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Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms

27 September 2017

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Mitotic control of dTTP pool: a necessity or coincidence?

27 September 2017

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Clonogenic assay of cells in vitro.

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Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction

27 September 2017

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Ribonucleotide reductase inhibitors and future drug design

27 September 2017

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DNA precursor metabolism and genomic stability

27 September 2017

1 reference

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Control of dTTP pool size by anaphase promoting complex/cyclosome is essential for the maintenance of genetic stability

27 September 2017

1 reference

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Stable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53(-/-) HCT-116 colon cancer cells to DNA-damaging agents and ribonucleotide reductase inhibitors

27 September 2017

1 reference

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S Phase-specific transcription of the mouse ribonucleotide reductase R2 gene requires both a proximal repressive E2F-binding site and an upstream promoter activating region

27 September 2017

1 reference

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Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins

27 September 2017

1 reference

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Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.

27 September 2017

1 reference

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Ribonucleotide reductase R2 protein is phosphorylated at serine-20 by P34cdc2 kinase

27 September 2017

1 reference

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Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A.

27 September 2017

1 reference

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Dissociation of centrosome replication events from cycles of DNA synthesis and mitotic division in hydroxyurea-arrested Chinese hamster ovary cells

27 September 2017

1 reference

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Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

27 September 2017

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International Commission for Protection Against Environmental Mutagens and Carcinogens. Deoxyribonucleoside triphosphate levels: a critical factor in the maintenance of genetic stability

27 September 2017

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Mutagenesis and deoxyribonucleotide pool imbalance

27 September 2017

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Interactions between deoxyribonucleotide and DNA synthesis

27 September 2017

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27 September 2017

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Molecular analysis of mutations in the hprt gene of V79 hamster fibroblasts: effects of imbalances in the dCTP, dGTP and dTTP pools

27 September 2017

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Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase

27 September 2017

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Controlled protein degradation regulates ribonucleotide reductase activity in proliferating mammalian cells during the normal cell cycle and in response to DNA damage and replication blocks

30 May 2018

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Phosphorylation of ribonucleotide reductase R2 protein: in vivo and in vitro evidence of a role for p34cdc2 and CDK2 protein kinases

30 May 2018

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30 May 2018

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30 May 2018

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Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress.

29 November 2018

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Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase

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Proteomic Analysis by Multidimensional Protein Identification Technology

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12 December 2020

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SnapShot: F Box Proteins II

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PubMed

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12 December 2020

inferred from PubMed ID database lookup

High-level expression and purification of recombinant SCF ubiquitin ligases

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https://api.crossref.org/works/10.1016%2FJ.CELL.2012.03.043

7 January 2021

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An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage

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Crossref

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7 January 2021

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Identifiers

DOI

10.1016/J.CELL.2012.03.043

1 reference

100893

100893

1 reference

1 reference

1 reference