PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice (Q24337364)

regulation of MAPK cascade

GOA release 2020-03-11

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GOA release 2020-03-11

1 reference

1 reference

Xin Li

1

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Payton D Stevens

2

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Jianyu Liu

3

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Haihua Yang

4

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Wei Wang

5

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Chi Wang

6

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Zheng Zeng

7

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Micheal D Schmidt

8

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Mike Yang

9

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Eun Y Lee

10

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Tianyan Gao

Comprehensive molecular characterization of human colon and rectal cancer

11

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language of work or name

English

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publication date

May 2014

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published in

Gastroenterology

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volume

146

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issue

5

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page(s)

1301-12.e1-10

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

Scribble-mediated membrane targeting of PHLPP1 is required for its negative regulation of Akt

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

PHLiPPing the switch on Akt and protein kinase C signaling

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

Lessons from hereditary colorectal cancer

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

Raf kinases in cancer-roles and therapeutic opportunities

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

The RAF proteins take centre stage

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

The phosphatase PHLPP1 regulates Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

Modeling oncogenic signaling in colon tumors by multidirectional analyses of microarray data directed for maximization of analytical reliability

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

The chromosomal instability pathway in colon cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

Epithelial to mesenchymal transition is impaired in colon cancer cells with microsatellite instability

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

Integrating signals from RTKs to ERK/MAPK.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

Akt signaling and cancer: surviving but not moving on.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

Positive and negative regulation of Raf kinase activity and function by phosphorylation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992173

High concordance of KRAS status between primary colorectal tumors and related metastatic sites: implications for clinical practice

27 September 2017

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24530606

12 December 2020

inferred from PubMed ID database lookup

Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening

1 reference

https://api.crossref.org/works/10.1053%2FJ.GASTRO.2014.02.003

7 January 2021

The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer

1 reference

https://api.crossref.org/works/10.1053%2FJ.GASTRO.2014.02.003

7 January 2021

Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1

1 reference

https://api.crossref.org/works/10.1053%2FJ.GASTRO.2014.02.003

7 January 2021

The phosphatase PHLPP controls the cellular levels of protein kinase C

1 reference

https://api.crossref.org/works/10.1053%2FJ.GASTRO.2014.02.003

7 January 2021

PHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growth

1 reference

https://api.crossref.org/works/10.1053%2FJ.GASTRO.2014.02.003

7 January 2021

mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways

1 reference

https://api.crossref.org/works/10.1053%2FJ.GASTRO.2014.02.003

7 January 2021

10.1053/J.GASTRO.2014.02.003

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

24530606

1 reference