Integrating signals from RTKs to ERK/MAPK. (Q34627656)

3 August 2017

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title

Integrating signals from RTKs to ERK/MAPK. (English)

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endosomal scaffold complex

3 August 2017

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Gene Ontology release 2020-05-02

McKay MM

1

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3 August 2017

Morrison DK

series ordinal

2

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3 August 2017

language of work or name

English

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publication date

1 May 2007

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3 August 2017

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3 August 2017

26

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3 August 2017

22

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3 August 2017

3113-3121

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210394

3 August 2017

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cites work

Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation

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7 January 2021

Molecular Mechanism for a Role of SHP2 in Epidermal Growth Factor Receptor Signaling

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7 January 2021

Compartmentalized signal transduction by receptor tyrosine kinases

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7 January 2021

Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1

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7 January 2021

PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.

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7 January 2021

A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14.

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7 January 2021

Regulation of ras signaling dynamics by Sos-mediated positive feedback

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7 January 2021

Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking

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7 January 2021

Ras signalling on the endoplasmic reticulum and the Golgi

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex

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7 January 2021

Murine Ksr interacts with MEK and inhibits Ras-induced transformation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Untying the regulation of the Raf-1 kinase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

A Ras-induced conformational switch in the Ras activator Son of sevenless

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

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7 January 2021

Erbin suppresses the MAP kinase pathway

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis

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7 January 2021

Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis

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7 January 2021

Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Differential modification of Ras proteins by ubiquitination

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Identification of a putative Syp substrate, the PDGF beta receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Coordinating ERK/MAPK signalling through scaffolds and inhibitors

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Mitogen-activated protein (MAP) kinase phosphorylation of MAP kinase kinase: determination of phosphorylation sites by mass spectrometry and site-directed mutagenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

1 reference

7 January 2021

Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Compartmentalized Ras/MAPK signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Regulation and targets of receptor tyrosine kinases

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Ras signaling from plasma membrane and endomembrane microdomains

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

CK2 Is a component of the KSR1 scaffold complex that contributes to Raf kinase activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Germline gain-of-function mutations in SOS1 cause Noonan syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

An acylation cycle regulates localization and activity of palmitoylated Ras isoforms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Regulation and role of Raf-1/B-Raf heterodimerization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Cell signaling by receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Structural analysis of autoinhibition in the Ras activator Son of sevenless

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Signal transduction and endocytosis: close encounters of many kinds

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Sef is a spatial regulator for Ras/MAP kinase signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Spred is a Sprouty-related suppressor of Ras signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

The RAF proteins take centre stage

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of Ras (KSR)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210394

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Dimensions Publication ID

3 August 2017

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1 reference