Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks (Q24337442)

1

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Michael Goldstein

2

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Peter Alexander

3

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Timothy P Wakeman

4

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Tao Sun

5

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Junjie Feng

6

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Zhenkun Lou

7

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Michael B Kastan

8

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Xiao-Fan Wang

The DNA-damage response in human biology and disease

9

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language of work or name

English

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publication date

16 April 2014

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published in

The EMBO Journal

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volume

33

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issue

8

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page(s)

862-77

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cites work

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Rapid activation of ATR by ionizing radiation requires ATM and Mre11

19 March 2017

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MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

19 March 2017

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The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

19 March 2017

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Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

19 March 2017

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Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization

19 March 2017

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Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

19 March 2017

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XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

19 March 2017

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The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

19 March 2017

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Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

19 March 2017

1 reference

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The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo.

19 March 2017

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The DNA Damage Response: Making It Safe to Play with Knives

19 March 2017

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

19 March 2017

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The mechanism of human nonhomologous DNA end joining

19 March 2017

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Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

19 March 2017

1 reference

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H2AX: the histone guardian of the genome

19 March 2017

1 reference

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Human Rad50/Mre11 is a flexible complex that can tether DNA ends

19 March 2017

1 reference

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AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses

19 March 2017

1 reference

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Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

Mechanism of eukaryotic homologous recombination

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

DNA repair pathways as targets for cancer therapy

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1.

7 April 2017

1 reference

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A role for the MRN complex in ATR activation via TOPBP1 recruitment

27 September 2017

1 reference

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The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

NBS1 directly activates ATR independently of MRE11 and TOPBP1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks

27 September 2017

1 reference

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BRCA1 and its toolbox for the maintenance of genome integrity

27 September 2017

1 reference

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MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

Crosstalk between histone modifications during the DNA damage response.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

DNA damage checkpoints in mammals

27 September 2017

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Fhit and CHK1 have opposing effects on homologous recombination repair

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

Genomic instability and endoreduplication triggered by RAD17 deletion

27 September 2017

1 reference

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DNA double-strand break repair signalling: the case of RAD51 post-translational regulation.

27 September 2017

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Rad52 protein associates with replication protein A (RPA)-single-stranded DNA to accelerate Rad51-mediated displacement of RPA and presynaptic complex formation

27 September 2017

1 reference

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Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

27 September 2017

1 reference

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HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma.

27 September 2017

1 reference

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Roles of ATM and ATR-mediated DNA damage responses during lytic BK polyomavirus infection

27 September 2017

1 reference

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Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

Control of sister chromatid recombination by histone H2AX.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

A novel role for Rad17 in homologous recombination.

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194111

NBS1 knockdown by small interfering RNA increases ionizing radiation mutagenesis and telomere association in human cells

29 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/24534091

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Human Rad17 is phosphorylated upon DNA damage and also overexpressed in primary non-small cell lung cancer tissues

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24534091