c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements (Q24337860)

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27 December 2019

title

c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements (English)

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27 December 2019

1 reference

GOA release 2020-03-11

SMAD binding

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GOA release 2020-03-11

author

Mitsuyasu Kato

4

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27 December 2019

Keiji Miyazawa

6

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27 December 2019

author name string

Hiroyuki Suzuki

1

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27 December 2019

Ken Yagi

2

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27 December 2019

Miki Kondo

3

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27 December 2019

Kohei Miyazono

5

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27 December 2019

language of work or name

English

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publication date

1 June 2004

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27 December 2019

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27 December 2019

volume

23

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27 December 2019

issue

29

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27 December 2019

page(s)

5068-5076

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c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads

27 December 2019

cites work

1 reference

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Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program

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Two short segments of Smad3 are important for specific interaction of Smad3 with c-Ski and SnoN

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Regulation of Smad7 promoter by direct association with Smad3 and Smad4.

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Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro

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Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts

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c-myc is a downstream target of the Smad pathway

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Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3.

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TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation

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7 January 2021

E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

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Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

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TGF-beta signalling from cell membrane to nucleus through SMAD proteins

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TGF-beta 1 inhibition of transin/stromelysin gene expression is mediated through a Fos binding sequence

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7 January 2021

Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2

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7 January 2021

Regulation of CSF1 promoter by the SWI/SNF-like BAF complex

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7 January 2021

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

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7 January 2021

Two major Smad pathways in TGF-beta superfamily signalling.

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7 January 2021

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

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7 January 2021

E1A inhibits transforming growth factor-beta signaling through binding to Smad proteins

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7 January 2021

Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor

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7 January 2021

TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains.

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7 January 2021

The Oncoprotein Ski Acts as an Antagonist of Transforming Growth Factor-β Signaling by Suppressing Smad2 Phosphorylation

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7 January 2021

TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

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7 January 2021

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

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7 January 2021

Repression of p15INK4b expression by Myc through association with Miz-1

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7 January 2021

Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein

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7 January 2021

Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling

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7 January 2021

Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia

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7 January 2021

Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski

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7 January 2021

Signal-dependent N-CoR Requirement for Repression by the Ski Oncoprotein

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7 January 2021

Direct interaction of Ski with either Smad3 or Smad4 is necessary and sufficient for Ski-mediated repression of transforming growth factor-beta signaling

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7 January 2021

Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207690

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15107821%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

27 December 2019

1011369399

0 references

1 reference