Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs (Q24338459)

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English	Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs	scientific article

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20 January 2020

Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs (English)

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20 January 2020

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Nuclear receptor subfamily 1 group H member 2

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GOA release 2020-03-11

Peroxisome proliferator activated receptor gamma

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GOA release 2020-03-11

Interferon gamma

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GOA release 2020-03-11

Nuclear receptor subfamily 1 group H member 3

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GOA release 2020-03-11

Signal transducer and activator of transcription 1

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GOA release 2020-03-11

negative regulation of interferon-gamma-mediated signaling pathway

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GOA release 2020-03-11

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based on heuristic

inferred from title

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20 January 2020

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Na Li

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20 January 2020

Rebecca C Salter

2

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1 February 2011

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20 January 2020

Journal of Cellular Biochemistry

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20 January 2020

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2

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675-683

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20 January 2020

Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein-delta gene in hepatocytes

1 reference

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The human leukemia cell line, THP-1: a multifacetted model for the study of monocyte-macrophage differentiation

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Integration of metabolism and inflammation by lipid-activated nuclear receptors

1 reference

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Inhibition of IFN-gamma-mediated inducible nitric oxide synthase induction by the peroxisome proliferator-activated receptor gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, involves inhibition of the upstream Janus kinase/STAT1 signaling pathw

1 reference

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21 January 2018

Critical role for casein kinase 2 and phosphoinositide-3-kinase in the interferon-gamma-induced expression of monocyte chemoattractant protein-1 and other key genes implicated in atherosclerosis

1 reference

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21 January 2018

Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors

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A critical role for the Sp1-binding sites in the transforming growth factor-beta-mediated inhibition of lipoprotein lipase gene expression in macrophages

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Anti-inflammatory effects of statins: clinical evidence and basic mechanisms

1 reference

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Upregulation of human angiotensinogen (AGT) gene transcription by interferon-gamma: involvement of the STAT1-binding motif in the AGT promoter.

1 reference

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21 January 2018

Tumor necrosis factor and interleukin 1 decrease RXRalpha, PPARalpha, PPARgamma, LXRalpha, and the coactivators SRC-1, PGC-1alpha, and PGC-1beta in liver cells

1 reference

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21 January 2018

Autoregulation of the human liver X receptor alpha promoter

1 reference

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21 January 2018

Simvastatin inhibits IFN-gamma-induced CD40 gene expression by suppressing STAT-1alpha

1 reference

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21 January 2018

The IFN-gamma-induced transcriptional program of the CIITA gene is inhibited by statins

1 reference

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21 January 2018

Differential SUMOylation of LXRalpha and LXRbeta mediates transrepression of STAT1 inflammatory signaling in IFN-gamma-stimulated brain astrocytes.

1 reference

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21 January 2018

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

1 reference

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21 January 2018

Gamma interferon: a central mediator in atherosclerosis

1 reference

https://api.crossref.org/works/10.1002%2FJCB.22976

21 January 2018

Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene

1 reference

https://api.crossref.org/works/10.1002%2FJCB.22976

21 January 2018

ERK is integral to the IFN-γ-mediated activation of STAT1, the expression of key genes implicated in atherosclerosis, and the uptake of modified lipoproteins by human macrophages

1 reference

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21 January 2018

Interferon gamma: a master regulator of atherosclerosis.

1 reference

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The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro.

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IL-33 reduces macrophage foam cell formation.

1 reference

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21 January 2018

Nuclear receptors: genomic and non-genomic effects converge.

1 reference

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21 January 2018

15-deoxy-Delta12,14-prostaglandin J2 inhibits INF-gamma-induced JAK/STAT1 signalling pathway activation and IP-10/CXCL10 expression in mesangial cells

1 reference

https://api.crossref.org/works/10.1002%2FJCB.22976

21 January 2018

A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma

1 reference

https://api.crossref.org/works/10.1002%2FJCB.22976

21 January 2018

Regulation of macrophage functions by PPAR-alpha, PPAR-gamma, and LXRs in mice and men.

1 reference

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21 January 2018

Inhibition of interferon-gamma-mediated microvascular endothelial cell major histocompatibility complex class II gene activation by HMG-CoA reductase inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FJCB.22976

21 January 2018

PPARgamma1 attenuates cytosol to membrane translocation of PKCalpha to desensitize monocytes/macrophages.

1 reference

https://api.crossref.org/works/10.1002%2FJCB.22976

21 January 2018

Casein-kinase-II-dependent phosphorylation of PPARgamma provokes CRM1-mediated shuttling of PPARgamma from the nucleus to the cytosol

1 reference

https://api.crossref.org/works/10.1002%2FJCB.22976

21 January 2018

PPARgamma is not required for the inhibitory actions of PGJ2 on cytokine signaling in pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1002%2FJCB.22976

21 January 2018

Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains

1 reference

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21 January 2018

Regulation of monocyte chemoattractant protein (MCP)-1 transcription by interferon-gamma (IFN-gamma) in human astrocytoma cells: postinduction refractory state of the gene, governed by its upstream elements

1 reference

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21 January 2018

Identifiers

10.1002/JCB.22976

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21268089%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21268089%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

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