Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis (Q24338676)

ubiquitin protein ligase activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Eun-Woo Lee

1

0 references

Min-Sik Lee

2

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Suzanne Camus

3

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Jaewang Ghim

4

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Mi-Ran Yang

5

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Wonkyung Oh

6

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Nam-Chul Ha

7

0 references

David P Lane

8

0 references

Jaewhan Song

Acetylation is indispensable for p53 activation

9

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language of work or name

English

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publication date

22 July 2009

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published in

The EMBO Journal

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volume

28

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issue

14

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page(s)

2100-13

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cites work

1 reference

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CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation

19 March 2017

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ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage

19 March 2017

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MSL2 promotes Mdm2-independent cytoplasmic localization of p53

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p53 Binding to the p21 promoter is dependent on the nature of DNA damage

27 September 2017

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Jab1 induces the cytoplasmic localization and degradation of p53 in coordination with Hdm2.

27 September 2017

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Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription.

27 September 2017

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The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression.

27 September 2017

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27 September 2017

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MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation

27 September 2017

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Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation.

27 September 2017

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27 September 2017

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Differences in the ubiquitination of p53 by Mdm2 and the HPV protein E6.

27 September 2017

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27 September 2017

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The association of p21((WAF-1/CIP1)) with progression to androgen-independent prostate cancer

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Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts

27 September 2017

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Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin

27 September 2017

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p21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents

27 September 2017

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Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2718286

Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2718286

Polycyclic aromatic hydrocarbon carcinogens increase ubiquitination of p21 protein after the stabilization of p53 and the expression of p21.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2718286

Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases

27 September 2017

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Proliferation- and apoptosis-associated factors in advanced prostatic carcinomas before and after androgen deprivation therapy: prognostic significance of p21/WAF1/CIP1 expression

27 September 2017

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Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice

27 September 2017

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Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation

27 September 2017

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Protective role of p21(Waf1/Cip1) against prostaglandin A2-mediated apoptosis of human colorectal carcinoma cells

27 September 2017

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The role of p53 inactivation in human cervical cell carcinoma development

27 September 2017

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Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT.

27 September 2017

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The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system

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Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio.

21 January 2018

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https://api.crossref.org/works/10.1038%2FEMBOJ.2009.164

SnapShot: p53 posttranslational modifications

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p21 modulates threshold of apoptosis induced by DNA-damage and growth factor withdrawal in prostate cancer cells

21 January 2018

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Makorin RING finger protein 1 (MKRN1) has negative and positive effects on RNA polymerase II-dependent transcription.

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MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.

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Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.

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Mutations in TP53, but not FGFR3, in urothelial cell carcinoma of the bladder are influenced by smoking: contribution of exogenous versus endogenous carcinogens.

21 January 2018

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ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling

21 January 2018

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p53 gene mutations in pontine gliomas of juvenile onset.

21 January 2018

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p53 mutations in all stages of thyroid carcinomas.

21 January 2018

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Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

21 January 2018

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Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

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Gender differences in p53 mutational status in small cell lung cancer

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12 December 2020

Differential effects of p21(WAF1/CIP1) deficiency on MMTV-ras and MMTV-myc mammary tumor properties

1 reference

12 December 2020

p21(Waf1/Cip1) protects against p53-mediated apoptosis of human melanoma cells

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12 December 2020

Aberrant p21(CIP1/WAF1) protein accumulation in head-and-neck cancer

1 reference

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Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis

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12 December 2020

Prognostic value and expression of p21(waf1/cip1) protein in prostate cancer

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12 December 2020

Direct proteasome inhibition by clasto-lactacystin beta-lactone permits the detection of ubiquitinated p21(waf1) in ML-1 cells

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Promoter hypermethylation of the DNA-repair gene O6-methylguanine-DNA methyltransferase and p53 mutation in diffuse large B-cell lymphoma

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12 December 2020

siRNA-mediated knockdown of Pdcd4 expression causes upregulation of p21(Waf1/Cip1) expression

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12 December 2020

Identifiers

DOI

10.1038/EMBOJ.2009.164

1 reference

3966585

3966585

1 reference

1 reference

1 reference