The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease (Q24339515)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21983832%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

title

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21983832%20AND%20SRC:MED&resulttype=core&format=json

inflammatory bowel diseases

14 February 2020

main subject

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0 references

2

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14 February 2020

Huaibin Cai

5

1 reference

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14 February 2020

author name string

Zhihua Liu

1

1 reference

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14 February 2020

Scott Krummey

3

1 reference

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14 February 2020

Wei Lu

4

1 reference

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14 February 2020

Michael J Lenardo

6

1 reference

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14 February 2020

language of work or name

English

0 references

publication date

9 October 2011

1 reference

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14 February 2020

1 reference

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14 February 2020

volume

12

1 reference

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14 February 2020

issue

11

1 reference

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14 February 2020

page(s)

1063-1070

1 reference

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Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression

14 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140245

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140245

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140245

A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140245

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140245

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140245

NFATc1 balances quiescence and proliferation of skin stem cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140245

A strategy for probing the function of noncoding RNAs finds a repressor of NFAT

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140245

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140245

Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140245

The transcription factor NF-ATc is essential for cardiac valve formation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140245

Transcription factors of the NFAT family: regulation and function

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140245

Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140245

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

19 March 2017

1 reference

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

22 April 2017

1 reference

Scaffold proteins: hubs for controlling the flow of cellular information

22 April 2017

1 reference

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

22 April 2017

1 reference

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

22 April 2017

1 reference

Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation

22 April 2017

1 reference

Inflammatory bowel disease

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140245

Transcriptional regulation by calcium, calcineurin, and NFAT

7 April 2017

1 reference

Genetic mapping in human disease

22 April 2017

1 reference

LRRK2 function on actin and microtubule dynamics in Parkinson disease

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140245

Calcineurin regulates innate antifungal immunity in neutrophils

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140245

Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140245

Molecular targets and regulators of cardiac hypertrophy.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140245

NFATc1 in inflammatory and musculoskeletal conditions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140245

Involvement of innate immunity in the development of inflammatory and autoimmune diseases.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140245

Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140245

Endoplasmic reticulum stress in the intestinal epithelium and inflammatory bowel disease

27 September 2017

1 reference

LRRK2 is involved in the IFN-gamma response and host response to pathogens

21 January 2018

1 reference

Regulation of the hypertonic stress response and other cellular functions by the Rel-like transcription factor NFAT5.

21 January 2018

1 reference

Age-dependent and cell-population-restricted LRRK2 expression in normal mouse spleen.

21 January 2018

1 reference

Role of M-CSF-dependent macrophages in colitis is driven by the nature of the inflammatory stimulus

21 January 2018

1 reference

Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis

21 January 2018

1 reference

NFAT1 and NFAT2 are positive regulators of IL-4 gene transcription

21 January 2018

1 reference

Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells

21 January 2018

1 reference

Validation of murine dextran sulfate sodium-induced colitis using four therapeutic agents for human inflammatory bowel disease

21 January 2018

1 reference

Effect of cyclosporin A on cell adhesion molecules and leukocyte-endothelial cell interactions in experimental colitis.

21 January 2018

1 reference

Cyclosporine regulates intestinal epithelial apoptosis via TGF-beta-related signaling

21 January 2018

1 reference

Aberrant activation of nuclear factor of activated T cell 2 in lamina propria mononuclear cells in ulcerative colitis

21 January 2018

1 reference

The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis

21 January 2018

1 reference

Parkinson disease, LRRK2 and the endocytic-autophagic pathway

21 January 2018

1 reference

CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation

21 January 2018

1 reference

Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21983832

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Meta-analysis of published studies identified eight additional common susceptibility loci for Crohn's disease and ulcerative colitis

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

The role of dendritic cells in the development of acute dextran sulfate sodium colitis

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NI.2113

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21983832%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21983832%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

PubMed publication ID

21983832

2 references