Killing tumours by ceramide-induced apoptosis: a critique of available drugs (Q24529892)

Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization

Europe PubMed Central

title

Killing tumours by ceramide-induced apoptosis: a critique of available drugs (English)

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Norman S Radin

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Norman S

Radin

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5 November 2023

language of work or name

English

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publication date

15 April 2003

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published in

Biochemical Journal

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volume

371

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issue

Pt 2

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page(s)

243-56

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cites work

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29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

L-Carnitine: a potential treatment for blocking apoptosis and preventing skeletal muscle myopathy in heart failure

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

Ex vivo localization of the mouse saposin C activation region for acid beta-glucosidase

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

Celecoxib exhibits the greatest potency amongst cyclooxygenase (COX) inhibitors for growth inhibition of COX-2-negative hematopoietic and epithelial cell lines

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

Ceramide involvement in homocamptothecin- and camptothecin-induced cytotoxicity and apoptosis in colon HT29 cells.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

Sphingomyelin enhances chemotherapy efficacy and increases apoptosis in human colonic tumor xenografts.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

Vitamin C stimulates sphingolipid production and markers of barrier formation in submerged human keratinocyte cultures

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

Induction of apoptosis by Phenothiazine derivatives in V79 cells

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

Apoptotic death by ceramide: will the real killer please stand up?

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

Possible involvement of ceramide in the regulation of rat Leydig cell function

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

Down-regulation of ceramide production abrogates ionizing radiation-induced cytochrome c release and apoptosis.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

Implication of mitochondria-derived reactive oxygen species, cytochrome C and caspase-3 in N-(4-hydroxyphenyl)retinamide-induced apoptosis in cervical carcinoma cells.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

Ceramide-beta-D-glucuronide: synthesis, digestion, and suppression of early markers of colon carcinogenesis.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

Reversal of radiation resistance in LNCaP cells by targeting apoptosis through ceramide synthase.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

L-carnitine prevents doxorubicin-induced apoptosis of cardiac myocytes: role of inhibition of ceramide generation.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

Modification of ceramide metabolism increases cancer cell sensitivity to cytotoxics.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

Perturbations in the control of cellular arachidonic acid levels block cell growth and induce apoptosis in HL-60 cells.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

N-Oleoylethanolamine inhibits glucosylation of natural ceramides in CHP-100 neuroepithelioma cells: possible implications for apoptosis.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

UVB irradiation up-regulates serine palmitoyltransferase in cultured human keratinocytes.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

Modulation of radiation response of human tumour cells by the differentiation inducers, phenylacetate and phenylbutyrate.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

Calcium Channel Blockers Induce Thymic Apoptosisin Vivoin Rats

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

Human glucocerebrosidase catalyses transglucosylation between glucocerebroside and retinol

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223313

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation

29 November 2018

1 reference

12 December 2020

Inhibition of experimental metastasis of murine Lewis lung carcinoma by an inhibitor of glucosylceramide synthase and its possible mechanism of action

1 reference

12 December 2020

Induction of apoptotic DNA fragmentation and cell death by natural ceramide

1 reference

12 December 2020

(1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase

1 reference

12 December 2020

Inhibitors of glucosylceramide synthase

1 reference

12 December 2020

Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway

1 reference

12 December 2020

Cytoplasmic induction and over-expression of cyclooxygenase-2 in human prostate cancer: implications for prevention and treatment

1 reference

12 December 2020

Changes in ceramide and sphingomyelin following fludarabine treatment of human chronic B-cell leukemia cells

1 reference

12 December 2020

Ultraviolet B radiation induces activation of neutral and acidic sphingomyelinases and ceramide generation in cultured normal human keratinocytes

1 reference

12 December 2020

Influence of cellular ganglioside depletion on tumor formation

1 reference

12 December 2020

Inhibition of phosphatidylcholine synthesis precedes apoptosis induced by C2-ceramide: protection by exogenous phosphatidylcholine

1 reference

12 December 2020

A metabolic role for mitochondria in palmitate-induced cardiac myocyte apoptosis

1 reference

12 December 2020

De novo-synthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinase

1 reference

12 December 2020

Ketoconazole-induced apoptosis through P53-dependent pathway in human colorectal and hepatocellular carcinoma cell lines

1 reference

12 December 2020

The topoisomerase I inhibitors, camptothecin and beta-lapachone, induce apoptosis of human retinal pigment epithelial cells

1 reference

12 December 2020

Daunorubicin- and mitoxantrone-triggered phosphatidylcholine hydrolysis: implication in drug-induced ceramide generation and apoptosis

1 reference

12 December 2020

Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486)

1 reference

12 December 2020

Dexamethasone-induced thymocyte apoptosis: apoptotic signal involves the sequential activation of phosphoinositide-specific phospholipase C, acidic sphingomyelinase, and caspases

1 reference

12 December 2020

Role of sphingosine 1-phosphate in the mitogenesis induced by oxidized low density lipoprotein in smooth muscle cells via activation of sphingomyelinase, ceramidase, and sphingosine kinase

1 reference

12 December 2020

On the prevention and therapy of prostate cancer by androgen administration

1 reference

12 December 2020

Myeloma cell growth arrest, apoptosis, and interleukin-6 receptor modulation induced by EB1089, a vitamin D3 derivative, alone or in association with dexamethasone

1 reference

12 December 2020

Combined effect of tamoxifen or interferon-beta and 4-hydroxyphenylretinamide on the growth of breast cancer cell lines

1 reference

12 December 2020

Tamoxifen activates cellular phospholipase C and D and elicits protein kinase C translocation

1 reference

12 December 2020

Sequential operation of ceramide synthesis and ICE cascade in CPT-11-initiated apoptotic death signaling

1 reference

12 December 2020

Oxidized low density lipoproteins stimulate galactosyltransferase activity, ras activation, p44 mitogen activated protein kinase and c-fos expression in aortic smooth muscle cells

1 reference

12 December 2020

Vitamin D3 and ceramide reduce the invasion of tumor cells through extracellular matrix components by elevating protein phosphatase-2A

1 reference

12 December 2020

Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death

1 reference

12 December 2020

Sphingolipids stimulate cell growth via MAP kinase activation in osteoblastic cells

1 reference

12 December 2020

Regulation of rheumatoid synovial cell growth by ceramide

1 reference

12 December 2020

The topoisomerase inhibitors camptothecin and etoposide induce a CD95-independent apoptosis of activated peripheral lymphocytes

1 reference

12 December 2020

Ceramide glycanase activities in human cancer cells

1 reference

12 December 2020

Androgen-induced growth inhibition of androgen receptor expressing androgen-independent prostate cancer cells is mediated by increased levels of neutral endopeptidase.

1 reference

12 December 2020

Comparison of different hydrophobic anchors conjugated to poly(ethylene glycol): effects on the pharmacokinetics of liposomal vincristine

1 reference

12 December 2020

Identifiers

DOI

10.1042/BJ20021878

1 reference

Consolidated OpenCitations Corpus – April 2017

release_hpkdpwbrbzb3lci5553kltn7km

3511925

Fatcat ID

0 references

3511925

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

0 references

1 reference