Role of helix P of the human cytomegalovirus DNA polymerase in resistance and hypersusceptibility to the antiviral drug foscarnet (Q24537618)

6 July 2017

title

Role of helix P of the human cytomegalovirus DNA polymerase in resistance and hypersusceptibility to the antiviral drug foscarnet (English)

1 reference

6 July 2017

0 references

3

Guy Boivin

1 reference

6 July 2017

Egor P Tchesnokov

1

1 reference

6 July 2017

Christian Gilbert

series ordinal

2

1 reference

6 July 2017

Matthias Götte

series ordinal

4

1 reference

6 July 2017

language of work or name

English

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publication date

1 February 2006

1 reference

6 July 2017

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6 July 2017

volume

80

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6 July 2017

issue

3

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6 July 2017

page(s)

1440-1450

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Human cytomegalovirus resistance to antiviral drugs

6 July 2017

cites work

1 reference

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Structure of the replicating complex of a pol alpha family DNA polymerase

24 March 2017

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Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69

24 March 2017

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24 March 2017

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Specific residues in the connector loop of the human cytomegalovirus DNA polymerase accessory protein UL44 are crucial for interaction with the UL54 catalytic subunit.

27 September 2017

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27 September 2017

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Relationship between 3′-Azido-3′-Deoxythymidine Resistance and Primer Unblocking Activity in Foscarnet-Resistant Mutants of Human Immunodeficiency Virus Type 1 Reverse Transcriptase

27 September 2017

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Amino acid changes within conserved region III of the herpes simplex virus and human cytomegalovirus DNA polymerases confer resistance to 4-oxo-dihydroquinolines, a novel class of herpesvirus antiviral agents

27 September 2017

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Resistance of herpesviruses to antiviral drugs: clinical impacts and molecular mechanisms

27 September 2017

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Cytomegalovirus (CMV) resistance to antivirals

27 September 2017

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Cytomegalovirus drug resistance and clinical implications

27 September 2017

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Resistance of human cytomegalovirus to antiviral drugs

27 September 2017

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The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: relationship to the structure of alpha-like DNA polymerases

27 September 2017

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Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments

27 September 2017

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In vitro expression of the human cytomegalovirus DNA polymerase gene: effects of sequence alterations on enzyme activity

27 September 2017

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Bacteriophage T4 DNA polymerase mutations that confer sensitivity to the PPi analog phosphonoacetic acid

27 September 2017

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A single-base change within the DNA polymerase locus of herpes simplex virus type 2 can confer resistance to aphidicolin

27 September 2017

1 reference

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Aphidicolin resistance in herpes simplex virus type 1 appears to alter substrate specificity in the DNA polymerase

27 September 2017

1 reference

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Mechanism of action of foscarnet against viral polymerases

27 September 2017

1 reference

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Mutational analysis of Lys65 of HIV-1 reverse transcriptase

27 September 2017

1 reference

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Expression of the catalytic subunit (UL54) and the accessory protein (UL44) of human cytomegalovirus DNA polymerase in a coupled in vitro transcription/translation system

30 May 2018

1 reference

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High-level resistance of cytomegalovirus to ganciclovir is associated with alterations in both the UL97 and DNA polymerase genes

30 May 2018

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Characterization of the DNA polymerases induced by a group of herpes simplex virus type I variants selected for growth in the presence of phosphonoformic acid

30 May 2018

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Pyrophosphate analogues as inhibitors of DNA polymerases of cytomegalovirus, herpes simplex virus and cellular origin

30 May 2018

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DNA polymerase insertion fidelity. Gel assay for site-specific kinetics

30 May 2018

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The structural mechanism of translocation and helicase activity in T7 RNA polymerase

30 May 2018

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Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1346920

Site-specific footprinting reveals differences in the translocation status of HIV-1 reverse transcriptase. Implications for polymerase translocation and drug resistance

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1346920

Mutations conferring foscarnet resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1346920

Correlation of the kinetics of finger domain mutants in RB69 DNA polymerase with its structure

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1346920

A point mutation in the human cytomegalovirus DNA polymerase gene selected in vitro by cidofovir confers a slow replication phenotype in cell culture

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1346920

Antiviral effects of phosphonoformate (PFA, foscarnet sodium)

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16415021

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Kinetic analysis of the interaction of cidofovir diphosphate with human cytomegalovirus DNA polymerase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16415021

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/JVI.80.3.1440-1450.2006

1 reference

6 July 2017

1 reference

6 July 2017

1 reference