Antithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation (Q24546028)

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Wei Li

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Ty E Adams

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James A Huntington

Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases

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language of work or name

English

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publication date

3 May 2006

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published in

The EMBO Journal

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volume

25

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issue

9

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page(s)

2029-37

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cites work

1 reference

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Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism

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Structure of a serpin-protease complex shows inhibition by deformation

24 March 2017

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The anticoagulant activation of antithrombin by heparin

24 March 2017

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N.m.r. and molecular-modelling studies of the solution conformation of heparin

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The Influence of Hinge Region Residue Glu-381 on Antithrombin Allostery and Metastability

24 March 2017

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Structure of beta-antithrombin and the effect of glycosylation on antithrombin's heparin affinity and activity

24 March 2017

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The structure of a Michaelis serpin-protease complex

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Crystal structures of human factor Xa complexed with potent inhibitors

24 March 2017

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Topography of a 2.0 Å structure of α1-antitrypsin reveals targets for rational drug design to prevent conformational disease

24 March 2017

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Likelihood-enhanced fast translation functions

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

24 March 2017

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An extensively modified version of MolScript that includes greatly enhanced coloring capabilities

24 March 2017

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Serpin structure, mechanism, and function

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The coagulation cascade: initiation, maintenance, and regulation

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Heparin overview and issues

24 March 2017

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Allosteric activation of antithrombin critically depends upon hinge region extension

27 September 2017

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The use of recombinant methods and molecular engineering in protein crystallization

27 September 2017

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The blood coagulation cascade

27 September 2017

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Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin.

27 September 2017

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The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity

27 September 2017

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A synthetic antithrombin III binding pentasaccharide is now a drug! What comes next?

27 September 2017

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Mutagenesis studies toward understanding the mechanism of differential reactivity of factor Xa with the native and heparin-activated antithrombin

27 September 2017

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Zymogenic and enzymatic properties of the 70-80 loop mutants of factor X/Xa

27 September 2017

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Mechanisms of glycosaminoglycan activation of the serpins in hemostasis

27 September 2017

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Heparin and calcium ions dramatically enhance antithrombin reactivity with factor IXa by generating new interaction exosites.

27 September 2017

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1976-1983, a critical period in the history of heparin: the discovery of the antithrombin binding site

27 September 2017

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Heparin activates antithrombin anticoagulant function by generating new interaction sites (exosites) for blood clotting proteinases.

27 September 2017

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Role of basic residues of the autolysis loop in the catalytic function of factor Xa.

27 September 2017

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Molecular determinants of the mechanism underlying acceleration of the interaction between antithrombin and factor Xa by heparin pentasaccharide

27 September 2017

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Partial activation of antithrombin without heparin through deletion of a unique sequence on the reactive site loop of the serpin

27 September 2017

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Conformational equilibrium of the reactive center loop of antithrombin examined by steady state and time-resolved fluorescence measurements: consequences for the mechanism of factor Xa inhibition by antithrombin-heparin complexes

27 September 2017

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The antithrombin P1 residue is important for target proteinase specificity but not for heparin activation of the serpin. Characterization of P1 antithrombin variants with altered proteinase specificity but normal heparin activation

27 September 2017

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Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence. Evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin

27 September 2017

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Calcium enhances heparin catalysis of the antithrombin-factor Xa reaction by promoting the assembly of an intermediate heparin-antithrombin-factor Xa bridging complex. Demonstration by rapid kinetics studies

27 September 2017

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Antithrombin and its inherited deficiency states.

27 September 2017

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Biochemical and pharmacological properties of SANORG 32701. Comparison with the "synthetic pentasaccharide' (SR 90107/ORG 31540) and standard heparin

27 September 2017

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Synthesis of heparin fragments. A chemical synthesis of the pentasaccharide O-(2-deoxy-2-sulfamido-6-O-sulfo-alpha-D-glucopyranosyl)-(1-4 )-O-(beta-D-glucopyranosyluronic acid)-(1-4)-O-(2-deoxy-2-sulfamido-3,6-di-O-sulfo-alpha-D-glu copyranosyl)-(1-

27 September 2017

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Converting blood coagulation factor IXa into factor Xa: dramatic increase in amidolytic activity identifies important active site determinants

27 September 2017

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Anti-thrombin activities of heparin. Effect of saccharide chain length on thrombin inhibition by heparin cofactor II and by antithrombin

30 May 2018

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Crystal structure of thrombin bound to heparin

30 May 2018

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Localization of an Antithrombin Exosite That Promotes Rapid Inhibition of Factors Xa and IXa Dependent on Heparin Activation of the Serpin

28 November 2018

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Heparin-induced substrate behavior of antithrombin Cambridge II.

28 November 2018

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Contribution of Basic Residues of the Autolysis Loop to the Substrate and Inhibitor Specificity of Factor IXa

28 November 2018

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Calcium enhances heparin catalysis of the antithrombin-factor Xa reaction by a template mechanism. Evidence that calcium alleviates Gla domain antagonism of heparin binding to factor Xa.

28 November 2018

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Antithrombin-heparin affinity reduced by fucosylation of carbohydrate at asparagine 155.

28 November 2018

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28 November 2018

Ion-pairs in proteins.

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Efficient expression system for human antithrombin III in baby hamster kidney cells

28 November 2018

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PubMed

12 December 2020

Biochemical and molecular aspects of the coagulation cascade

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PubMed

12 December 2020

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12 December 2020

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12 December 2020

Identification of basic residues in the heparin-binding exosite of factor Xa critical for heparin and factor Va binding

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PubMed

12 December 2020

Identifiers

DOI

10.1038/SJ.EMBOJ.7601089

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release_s65eko2cifdlnpdttxyckhhndq

661835

Fatcat ID

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661835

1 reference

1 reference

1 reference