Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases (Q24564290)

25 June 2017

Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases (English)

1 reference

25 June 2017

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4

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author name string

Kehao Zhao

1

1 reference

25 June 2017

Robyn Harshaw

2

1 reference

25 June 2017

Xiaomei Chai

3

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25 June 2017

Ronen Marmorstein

4

1 reference

25 June 2017

language of work or name

English

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publication date

18 May 2004

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Proceedings of the National Academy of Sciences of the United States of America

25 June 2017

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25 June 2017

101

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25 June 2017

23

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25 June 2017

8563-8568

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Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

25 June 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Negative control of p53 by Sir2alpha promotes cell survival under stress

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Structure of the histone deacetylase SIRT2

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Structure of the Yeast Hst2 Protein Deacetylase in Ternary Complex with 2′-O-Acetyl ADP Ribose and Histone Peptide

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Structure and autoregulation of the yeast Hst2 homolog of Sir2

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Structure of a Sir2 enzyme bound to an acetylated p53 peptide

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Structural basis for the NAD-dependent deacetylase mechanism of Sir2

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Crystal structure of a SIR2 homolog-NAD complex

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

24 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

24 March 2017

https://api.crossref.org/works/10.1073/PNAS.0401057101

Improved methods for building protein models in electron density maps and the location of errors in these models

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Identification of a small molecule inhibitor of Sir2p

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing

7 April 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

7 April 2017

https://api.crossref.org/works/10.1073%2FPNAS.0401057101

DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Genetics and the specificity of the aging process

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Sir2 links chromatin silencing, metabolism, and aging

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423234

Structural identification of 2'- and 3'-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta -NAD+-dependent histone/protein deacetylases

27 September 2017

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0401057101

Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0401057101

Mechanism of Nicotinamide Inhibition and Transglycosidation by Sir2 Histone/Protein Deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0401057101

Identification of Selective Inhibitors of NAD+-dependent Deacetylases Using Phenotypic Screens in Yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0401057101

Longevity research. In vino vitalis? Compounds activate life-extending genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0401057101

Inhibition of NAD glycohydrolase and ADP-ribosyl transferases by carbocyclic analogues of oxidized nicotinamide adenine dinucleotide

21 January 2018

1 reference

12 December 2020

Specific inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol

1 reference

12 December 2020

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

1 reference

12 December 2020

Role of NAD(+) in the deacetylase activity of the SIR2-like proteins

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0401057101

1 reference

OpenCitations bibliographic resource ID

25 June 2017

0 references

1806313

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference