Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism (Q24595310)

2

0 references

Smita Majumder

3

0 references

David X Medina

4

0 references

Walter Holbein

5

0 references

Andrea Magrí

6

0 references

Salvatore Oddo

Journal of Biological Chemistry

7

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language of work or name

English

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publication date

18 March 2011

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published in

0 references

volume

286

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page(s)

8924-32

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issue

11

0 references

describes a project that uses

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3058958/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding

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7 April 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease

27 September 2017

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Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets

27 September 2017

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A transient, neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis.

27 September 2017

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Excess protein synthesis in Drosophila fragile X mutants impairs long-term memory

27 September 2017

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30 May 2018

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Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease.

30 May 2018

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Detection and staging of dementia in Alzheimer's disease. Use of the neuropsychological measures developed for the Consortium to Establish a Registry for Alzheimer's Disease

30 May 2018

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Induction of matrix metalloproteinases (MMP3, MMP12 and MMP13) expression in the microglia by amyloid-beta stimulation via the PI3K/Akt pathway.

30 May 2018

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Effect of the Alzheimer amyloid fragment Abeta(25-35) on Akt/PKB kinase and survival of PC12 cells

21 January 2018

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Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology

21 January 2018

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mTOR signaling in epileptogenesis: too much of a good thing?

21 January 2018

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Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology.

21 January 2018

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Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice

21 January 2018

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Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

21 January 2018

1 reference

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Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease.

21 January 2018

1 reference

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Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice

21 January 2018

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Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology

21 January 2018

1 reference

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Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture

21 January 2018

1 reference

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Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.180638

TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.180638

Rapamycin inhibits mTORC1, but not completely.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.180638

Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058958

Amyloid beta oligomers induce impairment of neuronal insulin receptors

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21266573

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.180638

1 reference

93651

93651

1 reference

1 reference

1 reference