Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice (Q24600864)

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English	Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice	scientific article

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Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice (English)

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1

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Julien Hanson

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object named as

Sorin Tunaru

7

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object named as

Andreas Gille

2

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Stefan Offermanns

object named as

Stefan Offermanns

9

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Björn E Clausen

object named as

Björn E Clausen

5

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author name string

Sabrina Zwykiel

3

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Martina Lukasova

4

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Kashan Ahmed

6

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Angela Wirth

8

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publication date

August 2010

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Journal of Clinical Investigation

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120

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8

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2910-9

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beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

7 April 2017

GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

7 April 2017

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

7 April 2017

Nicotinic acid: pharmacological effects and mechanisms of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

7 April 2017

G13 is an essential mediator of platelet activation in hemostasis and thrombosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

7 April 2017

PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

7 April 2017

cDNA representational difference analysis of human neutrophils stimulated by GM-CSF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

7 April 2017

The analgesic effect profile of FR122047, a selective cyclooxygenase-1 inhibitor, in chemical nociceptive models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

7 April 2017

Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

7 April 2017

What's the deal with niacin development: is laropiprant add-on therapy a winning strategy to beat a straight flush?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

27 September 2017

The mechanism and mitigation of niacin-induced flushing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

27 September 2017

Extended-release niacin (nicotinic acid)/laropiprant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

27 September 2017

Nicotinic acid and the prevention of coronary artery disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

27 September 2017

Fumaric acid esters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

27 September 2017

The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

27 September 2017

Nicotinic acid, alone and in combinations, for reduction of cardiovascular risk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

27 September 2017

Niacin use and cutaneous flushing: mechanisms and strategies for prevention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

27 September 2017

Langerhans cells release prostaglandin D2 in response to nicotinic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

27 September 2017

Nicotinic acid-induced flushing is mediated by activation of epidermal langerhans cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

27 September 2017

Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

27 September 2017

Nicotinic acid: the broad-spectrum lipid drug. A 50th anniversary review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

27 September 2017

Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

27 September 2017

Niacin therapy in atherosclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

27 September 2017

Chimeric green fluorescent protein-aequorin as bioluminescent Ca2+ reporters at the single-cell level

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

27 September 2017

Rapid modification of bacterial artificial chromosomes by ET-recombination.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

27 September 2017

Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

27 September 2017

Modulation of keratinocyte proliferation in vitro by endogenous prostaglandin synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

27 September 2017

Prostaglandins contribute to the vasodilation induced by nicotinic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

27 September 2017

Dissociation of the effects of nicotinic acid on vasodilatation and lipolysis by a prostaglandin synthesis inhibitor, indomethacin, in man

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

27 September 2017

Studies on the Mechanism of Flush Induced by Nicotinic Acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

27 September 2017

G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

30 May 2018

PUMA-G, an IFN-gamma-inducible gene in macrophages is a novel member of the seven transmembrane spanning receptor superfamily

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

30 May 2018

Localization of prostaglandin-H synthase-1 and -2 in mouse skin: implications for cutaneous function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

30 May 2018

Cyclooxygenases in human and mouse skin and cultured human keratinocytes: association of COX-2 expression with human keratinocyte differentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

30 May 2018

Diphtheria toxin- and Pseudomonas A toxin-mediated apoptosis. ADP ribosylation of elongation factor-2 is required for DNA fragmentation and cell lysis and synergy with tumor necrosis factor-alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

28 November 2018

Effects of aspirin when added to the prostaglandin D2 receptor antagonist laropiprant on niacin-induced flushing symptoms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

28 November 2018

3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): a partial agonist of the nicotinic acid receptor, G-protein coupled receptor 109a, with antilipolytic but no vasodilatory activity in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

28 November 2018

Effects of laropiprant on nicotinic acid-induced flushing in patients with dyslipidemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

28 November 2018

Genetic deficiency or pharmacological inhibition of cyclooxygenase-1 or -2 induces mouse keratinocyte differentiation in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

28 November 2018

Apoptosis by leukemia cell-targeted diphtheria toxin occurs via receptor-independent activation of Fas-associated death domain protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

28 November 2018

Pharmacokinetics of enteric-coated aspirin and inhibition of platelet thromboxane A2 and vascular prostacyclin generation in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912194

28 November 2018

Biosynthesis and metabolism of prostaglandin E 2 in human skin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20664170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of prostaglandin-mediated vasodilatation in inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20664170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dose-related kinetics of aspirin. Presystemic acetylation of platelet cyclooxygenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20664170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization and distribution of prostaglandin D synthetase in rat skin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20664170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of eicosanoid generation by highly purified human Langerhans cells and keratinocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20664170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acipimox stimulates skin blood flow by a cyclo-oxygenase-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/20664170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tolerance to nicotinic acid flushing

1 reference

https://pubmed.ncbi.nlm.nih.gov/20664170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topical application of a selective cyclooxygenase inhibitor suppresses UVB mediated cutaneous inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20664170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/20664170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20664170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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