Structure of the human glucagon class B G-protein-coupled receptor (Q24601619)

9

0 references

Vadim Cherezov

13

0 references

Chris de Graaf

3

Chris de Graaf

0 references

Raymond C. Stevens

Raymond C Stevens

16

0 references

Qingping Xu

8

Qingping Xu

0 references

Fai Yiu Siu

1

Fai Yiu Siu

0 references

Gye Won Han

4

Gye Won Han

0 references

Wei Liu

11

Wei Liu

0 references

author name string

Min He

2

0 references

Dehua Yang

5

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Zhiyun Zhang

6

0 references

Caihong Zhou

7

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Jeremiah S Joseph

10

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Jesper Lau

12

0 references

Ming-Wei Wang

Molecular basis for negative regulation of the glucagon receptor

15

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language of work or name

English

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publication date

25 July 2013

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published in

Nature

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volume

499

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issue

7459

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page(s)

444-9

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cites work

1 reference

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Structure of the human κ-opioid receptor in complex with JDTic

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The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

7 April 2017

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Conformation of a peptide ligand bound to its G-protein coupled receptor

7 April 2017

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Structure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptors

7 April 2017

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Structure of the agonist-bound neurotensin receptor

7 April 2017

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Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

7 April 2017

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Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor

7 April 2017

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Linking Crystallographic Model and Data Quality

7 April 2017

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Features and development of Coot

7 April 2017

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Phasercrystallographic software

7 April 2017

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Refinement of macromolecular structures by the maximum-likelihood method

7 April 2017

1 reference

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Iterative model building, structure refinement and density modification with the PHENIX AutoBuild wizard

7 April 2017

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Three distinct epitopes on the extracellular face of the glucagon receptor determine specificity for the glucagon amino terminus

7 April 2017

1 reference

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Characterization of glucagon-like peptide-1 receptor-binding determinants

7 April 2017

1 reference

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Characterization of a novel, non-peptidyl antagonist of the human glucagon receptor

7 April 2017

1 reference

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OPM database and PPM web server: resources for positioning of proteins in membranes

7 April 2017

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Roles of specific extracellular domains of the glucagon receptor in ligand binding and signaling

7 April 2017

1 reference

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The amazing diversity of cap-independent translation elements in the 3'-untranslated regions of plant viral RNAs

7 April 2017

1 reference

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The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints

22 April 2017

1 reference

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Decision-making in structure solution using Bayesian estimates of map quality: the PHENIX AutoSol wizard

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820480

Crystallizing membrane proteins using lipidic mesophases

7 April 2017

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Structural diversity of G protein-coupled receptors and significance for drug discovery

7 April 2017

1 reference

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Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

7 April 2017

1 reference

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Molecular signatures of G-protein-coupled receptors

27 September 2017

1 reference

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Structure-function of the G protein-coupled receptor superfamily

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820480

Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820480

Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820480

Targeting the glucagon receptor family for diabetes and obesity therapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820480

phenix.mr_rosetta: molecular replacement and model rebuilding with Phenix and Rosetta

27 September 2017

1 reference

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Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation

27 September 2017

1 reference

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Site of action of a pentapeptide agonist at the glucagon-like peptide-1 receptor. Insight into a small molecule agonist-binding pocket

27 September 2017

1 reference

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Molecular basis of secretin docking to its intact receptor using multiple photolabile probes distributed throughout the pharmacophore

27 September 2017

1 reference

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Refinement of glucagon-like peptide 1 docking to its intact receptor using mid-region photolabile probes and molecular modeling

27 September 2017

1 reference

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Charge inversion at position 68 of the glucagon and glucagon-like peptide-1 receptors supports selectivity in hormone action.

27 September 2017

1 reference

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Mutational and cysteine scanning analysis of the glucagon receptor N-terminal domain

27 September 2017

1 reference

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Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam.

27 September 2017

1 reference

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Passing the baton in class B GPCRs: peptide hormone activation via helix induction?

27 September 2017

1 reference

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The JCSG MR pipeline: optimized alignments, multiple models and parallel searches

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820480

Structural basis of natural ligand binding and activation of the Class II G-protein-coupled secretin receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820480

Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820480

Detergents Destabilize the Cubic Phase of Monoolein: Implications for Membrane Protein Crystallization

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820480

A point mutation in the glucose-dependent insulinotropic peptide receptor confers constitutive activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820480

Residues within the transmembrane domain of the glucagon-like peptide-1 receptor involved in ligand binding and receptor activation: modelling the ligand-bound receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820480

Development of an Automated High Throughput LCP-FRAP Assay to Guide Membrane Protein Crystallization in Lipid Mesophases

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820480

Development of a new physics-based internal coordinate mechanics force field and its application to protein loop modeling

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820480

Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820480

Protean effects of a natural peptide agonist of the G protein-coupled secretin receptor demonstrated by receptor mutagenesis.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820480

Identification of determinants of glucose-dependent insulinotropic polypeptide receptor that interact with N-terminal biologically active region of the natural ligand.

30 May 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12393

Identification of a contact site for residue 19 of parathyroid hormone (PTH) and PTH-related protein analogs in transmembrane domain two of the type 1 PTH receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12393

Structure-Based Discovery of Allosteric Modulators of Two Related Class B G-Protein-Coupled Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12393

Development of potent truncated glucagon antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12393

Mutational analysis of the glucagon receptor: similarities with the vasoactive intestinal peptide (VIP)/pituitary adenylate cyclase-activating peptide (PACAP)/secretin receptors for recognition of the ligand's third residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12393

Two basic residues of the h-VPAC1 receptor second transmembrane helix are essential for ligand binding and signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12393

Spatial proximity between the VPAC1 receptor and the amino terminus of agonist and antagonist peptides reveals distinct sites of interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12393

Diffuse pharmacophoric domains of vasoactive intestinal peptide (VIP) and further insights into the interaction of VIP with the N-terminal ectodomain of human VPAC1 receptor by photoaffinity labeling with [Bpa6]-VIP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12393

A robotic system for crystallizing membrane and soluble proteins in lipidic mesophases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12393

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12393

Mutations of aromatic residues in the first transmembrane helix impair signalling by the secretin receptor

21 January 2018

1 reference

12 December 2020

Role of charged amino acids conserved in the vasoactive intestinal polypeptide/secretin family of receptors on the secretin receptor functionality

1 reference

12 December 2020

Class-B GPCR activation: is ligand helix-capping the key?

1 reference

12 December 2020

Analysis of the glucagon receptor first extracellular loop by the substituted cysteine accessibility method

1 reference

12 December 2020

Scanning of the glucagon-like peptide-1 receptor localizes G protein-activating determinants primarily to the N terminus of the third intracellular loop

1 reference

12 December 2020

Contribution of the second transmembrane helix of the secretin receptor to the positioning of secretin

1 reference

12 December 2020

Identifiers

DOI

10.1038/NATURE12393

1 reference

Dimensions Publication ID

1138264

1049819195

0 references

1138264

1 reference

1 reference

1 reference