TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo (Q24606587)

GOA release 2020-03-11

tripeptidyl peptidase 1

1 reference

protein localization to chromosome, telomeric region

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

4

Gaël Cristofari

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author name string

Eladio Abreu

1

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Elena Aritonovska

2

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Patrick Reichenbach

3

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Brad Culp

5

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Rebecca M Terns

6

0 references

Joachim Lingner

7

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Michael P Terns

Molecular and Cellular Biology

8

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language of work or name

English

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publication date

June 2010

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published in

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volume

30

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issue

12

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page(s)

2971-82

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cites work

Telomere protection by TPP1 is mediated by POT1a and POT1b

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A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis

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TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita

7 April 2017

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Telomere protection by mammalian Pot1 requires interaction with Tpp1

7 April 2017

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The POT1-TPP1 telomere complex is a telomerase processivity factor

7 April 2017

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TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase

7 April 2017

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The human RNA surveillance factor UPF1 is required for S phase progression and genome stability

7 April 2017

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Cell cycle-regulated trafficking of human telomerase to telomeres

7 April 2017

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Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeres

7 April 2017

1 reference

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POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

PTOP interacts with POT1 and regulates its localization to telomeres

7 April 2017

1 reference

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TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex

7 April 2017

1 reference

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POT1 as a terminal transducer of TRF1 telomere length control

7 April 2017

1 reference

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Human telomerase and its regulation

7 April 2017

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Human telomerase contains two cooperating telomerase RNA molecules

7 April 2017

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Control of human telomere length by TRF1 and TRF2

7 April 2017

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Extension of life-span by introduction of telomerase into normal human cells

7 April 2017

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Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

7 April 2017

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Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

7 April 2017

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Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression.

7 April 2017

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The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo

7 April 2017

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Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance

7 April 2017

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Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends

7 April 2017

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7 April 2017

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Shelterin: the protein complex that shapes and safeguards human telomeres

7 April 2017

1 reference

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Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

TIN2 mediates functions of TRF2 at human telomeres

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

Expression of POT1 is associated with tumor stage and telomere length in gastric carcinoma

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

Pot1, the putative telomere end-binding protein in fission yeast and humans

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

How shelterin protects mammalian telomeres

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

Telomerase mutations in families with idiopathic pulmonary fibrosis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

Regulation of telomerase by telomeric proteins

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

A DNA damage checkpoint response in telomere-initiated senescence

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

DNA damage foci at dysfunctional telomeres

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

Reverse transcriptase motifs in the catalytic subunit of telomerase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

27 September 2017

Telomeres and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

Rapid Cdc13 turnover and telomere length homeostasis are controlled by Cdk1-mediated phosphorylation of Cdc13.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

The telosome/shelterin complex and its functions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

Telomerase reverse transcriptase is required for the localization of telomerase RNA to cajal bodies and telomeres in human cancer cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

Dyskeratosis congenita: the diverse clinical presentation of mutations in the telomerase complex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

Telomere length homeostasis requires that telomerase levels are limiting

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

Telomerase RNA Accumulates in Cajal Bodies in Human Cancer Cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

Cdc13 both positively and negatively regulates telomere replication

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

Microinjection of anti-coilin antibodies affects the structure of coiled bodies

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body-specific localization signal.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

Telomerase recruitment by the telomere end binding protein-beta facilitates G-quadruplex DNA unfolding in ciliates.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876666

Human telomerase RNA accumulation in Cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20404094

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regions

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20404094