LGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/β-catenin signaling (Q24606839)

2

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Xing Gong

3

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Anthony Thomas

4

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Qingyun Liu

Molecular and Cellular Biology

5

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language of work or name

English

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publication date

June 2012

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published in

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volume

32

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page(s)

2054-64

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issue

11

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describes a project that uses

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3372227/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

7 April 2017

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R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6

7 April 2017

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7 April 2017

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Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin

7 April 2017

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Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression

7 April 2017

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Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distension

7 April 2017

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7 April 2017

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Identification and cloning of an orphan G protein-coupled receptor of the glycoprotein hormone receptor subfamily

7 April 2017

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7 April 2017

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

7 April 2017

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7 April 2017

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High mobility group box 1 protein interacts with multiple Toll-like receptors

7 April 2017

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7 April 2017

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Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

7 April 2017

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7 April 2017

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Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region

7 April 2017

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Secreted frizzled-related protein 4 regulates two Wnt7a signaling pathways and inhibits proliferation in endometrial cancer cells

7 April 2017

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7 April 2017

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Endocytosis and signalling: intertwining molecular networks

7 April 2017

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Dynasore, a cell-permeable inhibitor of dynamin

7 April 2017

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A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

7 April 2017

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Wnt proteins are lipid-modified and can act as stem cell growth factors

7 April 2017

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Caveolin, a protein component of caveolae membrane coats

7 April 2017

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LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.

7 April 2017

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The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse

27 September 2017

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Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells

27 September 2017

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Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in colorectal cancer

27 September 2017

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27 September 2017

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Development of a bioassay for detection of Wnt-binding affinities for individual frizzled receptors

27 September 2017

1 reference

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27 September 2017

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27 September 2017

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G-protein-coupled receptor GPR49 is up-regulated in basal cell carcinoma and promotes cell proliferation and tumor formation.

27 September 2017

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R-Spondin family members regulate the Wnt pathway by a common mechanism

27 September 2017

1 reference

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Endocytosis: a positive or a negative influence on Wnt signalling?

27 September 2017

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MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer.

27 September 2017

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Clathrin-dependent mechanisms of G protein-coupled receptor endocytosis

27 September 2017

1 reference

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A critical role for endocytosis in Wnt signaling

27 September 2017

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Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors

27 September 2017

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R-Spondin proteins: a novel link to beta-catenin activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372227

R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372227

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27 September 2017

1 reference

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Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372227

R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372227

Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372227

Wnt signaling and stem cell control

28 November 2018

1 reference

PubMed

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