How insulin engages its primary binding site on the insulin receptor (Q24609714)

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Michael C Lawrence

object named as

Michael C Lawrence

17

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author name string

Jonathan Whittaker

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Mai B Margetts

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Linda J Whittaker

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Geoffrey K-W Kong

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Christopher J Watson

7

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Lenka Záková

8

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Emília Kletvíková

9

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Jiří Jiráček

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Shu Jin Chan

11

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Donald F Steiner

12

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Guy G Dodson

13

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Andrzej M Brzozowski

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Michael A Weiss

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Colin W Ward

Cell signaling by receptor tyrosine kinases

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language of work or name

English

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publication date

10 January 2013

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published in

Nature

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volume

493

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page(s)

241-5

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issue

7431

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cites work

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Critical nodes in signalling pathways: insights into insulin action

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α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase

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Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

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27 September 2017

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High-affinity insulin binding: insulin interacts with two receptor ligand binding sites

27 September 2017

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30 May 2018

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Structure of Rhombohedral 2 Zinc Insulin Crystals

30 May 2018

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Alternative splicing of human insulin receptor messenger RNA.

21 January 2018

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21 January 2018

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Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains

21 January 2018

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Diabetes-associated mutations in insulin identify invariant receptor contacts.

21 January 2018

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Insulin analogues with modifications at position B26. Divergence of binding affinity and biological activity

21 January 2018

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Template convolution to enhance or detect structural features in macromolecular electron-density maps.

21 January 2018

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A thermodynamic study of ligand binding to the first three domains of the human insulin receptor: relationship between the receptor alpha-chain C-terminal peptide and the site 1 insulin mimetic peptides.

21 January 2018

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Biochemistry. Resolving some old problems in protein crystallography

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/23302862

12 December 2020

inferred from PubMed ID database lookup

Specificity of insulin and insulin-like growth factor I receptors investigated using chimeric mini-receptors. Role of C-terminal of receptor alpha subunit

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23302862

12 December 2020

inferred from PubMed ID database lookup

A model for insulin binding to the insulin receptor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23302862

12 December 2020

inferred from PubMed ID database lookup

Global indicators of X-ray data quality

1 reference

https://api.crossref.org/works/10.1038%2FNATURE11781

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NATURE11781

1 reference

Dimensions Publication ID

394660

1022467752

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394660

1 reference

1 reference

1 reference