Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline (Q35858095)

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scientific article published in April 2012

Language	Label	Description	Also known as
English	Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline	scientific article published in April 2012

Statements

scholarly article

1 reference

Europe PubMed Central

10 August 2017

Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline (English)

1 reference

Europe PubMed Central

10 August 2017

Alzheimer's disease

0 references

1 reference

based on heuristic

inferred from title

insulin resistance

1 reference

based on heuristic

inferred from title

John Q. Trojanowski

15

object named as

John Q Trojanowski

1 reference

Europe PubMed Central

10 August 2017

Steven E. Arnold

16

object named as

Steven E Arnold

1 reference

Europe PubMed Central

10 August 2017

David A Bennett

14

object named as

David A Bennett

1 reference

Europe PubMed Central

10 August 2017

Julie A Schneider

12

object named as

Julie A Schneider

1 reference

Europe PubMed Central

10 August 2017

Robert S Wilson

10

object named as

Robert S Wilson

1 reference

Europe PubMed Central

10 August 2017

Zoe Arvanitakis

11

object named as

Zoe Arvanitakis

1 reference

Europe PubMed Central

10 August 2017

author name string

Konrad Talbot

1

1 reference

Europe PubMed Central

10 August 2017

Hoau-Yan Wang

2

1 reference

Europe PubMed Central

10 August 2017

Hala Kazi

3

1 reference

Europe PubMed Central

10 August 2017

Li-Ying Han

4

1 reference

Europe PubMed Central

10 August 2017

Kalindi P Bakshi

5

1 reference

Europe PubMed Central

10 August 2017

Andres Stucky

6

1 reference

Europe PubMed Central

10 August 2017

Robert L Fuino

7

1 reference

Europe PubMed Central

10 August 2017

Krista R Kawaguchi

8

1 reference

Europe PubMed Central

10 August 2017

Andrew J Samoyedny

9

1 reference

Europe PubMed Central

10 August 2017

Bryan A Wolf

13

1 reference

Europe PubMed Central

10 August 2017

language of work or name

0 references

publication date

1 April 2012

1 reference

Europe PubMed Central

10 August 2017

Journal of Clinical Investigation

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Europe PubMed Central

10 August 2017

122

1 reference

Europe PubMed Central

10 August 2017

1316-1338

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Europe PubMed Central

10 August 2017

4

1 reference

Europe PubMed Central

10 August 2017

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

1 reference

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Insulin resistance and pathological brain ageing

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27 July 2018

Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial

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Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: the Framingham Offspring Study

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Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

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Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

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Dementia, diabetes, Alzheimer's disease, and insulin resistance in the brain: progress, dilemmas, new opportunities, and a hypothesis to tackle intersecting epidemics.

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Insulin-resistant brain state: the culprit in sporadic Alzheimer's disease?

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Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes.

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Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease.

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Analysis of microdissected human neurons by a sensitive ELISA reveals a correlation between elevated intracellular concentrations of Abeta42 and Alzheimer's disease neuropathology

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Irs1 serine 307 promotes insulin sensitivity in mice

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Reduced IGF-1 signaling delays age-associated proteotoxicity in mice

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Insulin resistance and Alzheimer's disease

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Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation

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Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent

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Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin.

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Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention

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Pathophysiology of prediabetes

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The many ways to regulate glucose transporter 4.

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A comprehensive definition for metabolic syndrome.

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Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}

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Cerebellar neurons possess a vesicular compartment structurally and functionally similar to Glut4-storage vesicles from peripheral insulin-sensitive tissues.

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Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders

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The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events

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Phosphorylation of IRS proteins Yin-Yang regulation of insulin signaling

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Serine kinases of insulin receptor substrate proteins

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Alterations of insulin signaling in type 2 diabetes: a review of the current evidence from humans

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Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease

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Full accounting of diabetes and pre-diabetes in the U.S. population in 1988-1994 and 2005-2006

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Insulin resistance and Alzheimer's disease: molecular links & clinical implications.

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Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology

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Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

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Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

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IRS1-independent defects define major nodes of insulin resistance

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Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer's disease: insights from functional MRI studies

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GLP-1 amplifies insulin signaling by up-regulation of IRbeta, IRS-1 and Glut4 in 3T3-L1 adipocytes

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Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach

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Short-term in vitro inhibition of glycogen synthase kinase 3 potentiates insulin signaling in type I skeletal muscle of Zucker Diabetic Fatty rats

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Differential activation of insulin receptor substrates 1 and 2 by insulin-like growth factor-activated insulin receptors.

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Pathophysiology of insulin resistance.

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Therapy Insight: type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease

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Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

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Risk of dementia in diabetes mellitus: a systematic review

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Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine

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Insulin resistance syndrome and Alzheimer's disease: age- and obesity-related effects on memory, amyloid, and inflammation

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Differential activation of insulin receptor isoforms by insulin-like growth factors is determined by the C domain

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Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain

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The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex

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Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?

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Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

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Pathogenesis of type 2 diabetes mellitus

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Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B

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Insulin-like growth factor 1 regulates developing brain glucose metabolism

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Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes

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Immunocytochemical localization of the insulin-responsive glucose transporter 4 (Glut4) in the rat central nervous system.

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Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

27 July 2018

Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: cross sectional population based study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

27 July 2018

The cerebellum in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

27 July 2018

Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

27 July 2018

Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

27 July 2018

Insulin receptor substrate-1 (IRS-1) distribution in the rat central nervous system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

27 July 2018

Insulin action and the insulin signaling network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

27 July 2018

Molecular and cellular aspects of the insulin-like growth factor I receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

27 July 2018

Insulin in Brain and Other Extrapancreatic Tissues of Vertebrates and Nonvertebrates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

27 July 2018

Stimulation of deoxy[3H]glucose uptake into slices from cerebral cortex elicited by excitatory amino acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

27 July 2018

High-affinity transport and phosphorylation of 2-deoxy-D-glucose in synaptosomes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

27 July 2018

Insulin receptors in the mammalian central nervous system: binding characteristics and subunit structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

27 July 2018

Insulin in the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

27 July 2018

Glucose transport in primary cultured neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

27 July 2018

Insulin-like growth factor I (IGF-I) distribution in the tissue and extracellular compartment in different regions of rat brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

27 July 2018

Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

27 July 2018

The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

27 July 2018

Neuropathological stageing of Alzheimer-related changes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

27 July 2018

Glucose tolerance status and risk of dementia in the community: the Hisayama study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Insulin-activated Akt rescues Aβ oxidative stress-induced cell death by orchestrating molecular trafficking.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Effects of insulin and amyloid β(1-42) oligomers on glucose incorporation and mitochondrial function in cultured rat hippocampal neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Effects of high-fat diet on insulin receptor function in rat hippocampus and the level of neuronal corticosterone.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

The role of GLP-1 in neuronal activity and neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

The amnestic syndrome of hippocampal type in Alzheimer's disease: an MRI study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

How does diabetes accelerate Alzheimer disease pathology?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Diabetes, Alzheimer disease, and vascular dementia: a population-based neuropathologic study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Pathogenesis of insulin resistance in skeletal muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Amyloid beta oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Dissociating beta-amyloid from alpha 7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes alpha 7 nicotinic acetylcholine and NMDA receptor function in Alzheimer's disease brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Neuronal glucose but not lactate utilization is positively correlated with NMDA-induced neurotransmission and fluctuations in cytosolic Ca2+ levels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Rate of progression of mild cognitive impairment to dementia--meta-analysis of 41 robust inception cohort studies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Calcineurin mediates AKT dephosphorylation in the ischemic rat retina

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

The insulin-regulated aminopeptidase IRAP is colocalised with GLUT4 in the mouse hippocampus--potential role in modulation of glucose uptake in neurones?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Power of pairwise comparisons in the equal variance and unequal sample size case.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

SH3 domain of the phosphatidylinositol 3-kinase regulatory subunit is responsible for the formation of a sequestration complex with insulin receptor substrate-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Abeta(1-42) stimulated T cells express P-PKC-delta and P-PKC-zeta in Alzheimer disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Dephosphorylation by default, a potential mechanism for regulation of insulin receptor substrate-1/2, Akt, and ERK1/2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Critical nodes in signalling pathways: insights into insulin action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Muscle cell depolarization induces a gain in surface GLUT4 via reduced endocytosis independently of AMPK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Insulin regulates neuronal glucose uptake by promoting translocation of glucose transporter GLUT3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Identification of phosphorylation sites in insulin receptor substrate-1 by hypothesis-driven high-performance liquid chromatography-electrospray ionization tandem mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

A biochemical and functional characterization of diet-induced brain insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Inflammation and nitric oxide production in skeletal muscle of type 2 diabetic patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Akt activity in Alzheimer's disease and other neurodegenerative disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Increased risk of type 2 diabetes in Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Role of protein kinase B in Alzheimer's neurofibrillary pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Expression of insulin-responsive glucose transporter GLUT4 mRNA in the rat brain and spinal cord: an in situ hybridization study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Phases of A beta-deposition in the human brain and its relevance for the development of AD.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Immunohistochemical localization and quantification of glucose transporters in the mouse brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) by oxidant stress in cerebellar granule neurons: modulation by N-methyl-D-aspartate through calcineurin activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

ELISA-quantitation of phosphorylated tau protein in the Alzheimer's disease brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Insulin-sensitive GLUT4 glucose transporters are colocalized with GLUT3-expressing cells and demonstrate a chemically distinct neuron-specific localization in rat brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Phosphatidylinositol 3-kinase-mediated regulation of neuronal apoptosis and necrosis by insulin and IGF-I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Quantitative autoradiographic localization of [125I]insulin-like growth factor I, [125I]insulin-like growth factor II, and [125I]insulin receptor binding sites in developing and adult rat brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Structural differences between insulin receptors in the brain and peripheral target tissues.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Alternative splicing of human insulin receptor messenger RNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Hippocampal formation: anatomy and the patterns of pathology in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314463

24 September 2018

Amyloid beta oligomers induce impairment of neuronal insulin receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22476197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/22476197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular basis of insulin action

1 reference

https://pubmed.ncbi.nlm.nih.gov/22476197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the glucose transporter from rat brain synaptosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22476197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The carboxyl terminus of GLUT4 contains a serine-leucine-leucine sequence that functions as a potent internalization motif in Chinese hamster ovary cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22476197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exenatide prevents fat-induced insulin resistance and raises adiponectin expression and plasma levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/22476197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/22476197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI59903

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

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