Protean PTEN: form and function (Q24613810)

American Journal of Human Genetics

Europe PubMed Central

title

Protean PTEN: form and function (English)

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Charis Eng

2

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author name string

Kristin A Waite

series ordinal

1

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language of work or name

English

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publication date

April 2002

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published in

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volume

70

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issue

4

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page(s)

829-44

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cites work

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Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2

7 April 2017

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Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase

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The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

7 April 2017

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The lipid phosphatase activity of PTEN is critical for its tumor supressor function

7 April 2017

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Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

7 April 2017

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

7 April 2017

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7 April 2017

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P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

7 April 2017

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TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta

7 April 2017

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Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

7 April 2017

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Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

7 April 2017

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

7 April 2017

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7 April 2017

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Male breast cancer in Cowden syndrome patients with germline PTEN mutations

7 April 2017

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PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model

7 April 2017

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Novel germline mutations in the PTEN tumour suppressor gene found in women with multiple cancers

7 April 2017

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PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway

7 April 2017

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

7 April 2017

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Pten is essential for embryonic development and tumour suppression

7 April 2017

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Genetics of Cowden syndrome: through the looking glass of oncology

7 April 2017

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Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

7 April 2017

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7 April 2017

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Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis

7 April 2017

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Regulation of PTEN transcription by p53

7 April 2017

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Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay

7 April 2017

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Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

7 April 2017

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7 April 2017

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A role for nuclear PTEN in neuronal differentiation.

7 April 2017

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The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains

7 April 2017

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7 April 2017

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7 January 2021

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C2-domains, structure and function of a universal Ca2+-binding domain

1 reference

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Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Interpreting epidemiological research: blinded comparison of methods used to estimate the prevalence of inherited mutations in BRCA1.

7 April 2017

1 reference

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A novel germline mutation of the PTEN gene in a patient with macrocephaly, ventricular dilatation, and features of VATER association

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

27 September 2017

1 reference

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Transduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activation

27 September 2017

1 reference

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Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.

27 September 2017

1 reference

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Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Profiling the downstream genes of tumor suppressor PTEN in lung cancer cells by complementary DNA microarray

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Mutations of the human PTEN gene

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

The generation of lipid signaling molecules in the nucleus

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

PI-3 kinase in signal transduction, cell transformation, and as a target for chemoprevention of cancer.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A Gbetagamma-dependent pathway that requires the p110gamma amino terminus

27 September 2017

1 reference

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Protein modules as organizers of membrane structure

27 September 2017

1 reference

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PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Proteus syndrome: diagnostic criteria, differential diagnosis, and patient evaluation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Phenotypic findings of Cowden syndrome and Bannayan-Zonana syndrome in a family associated with a single germline mutation in PTEN

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Mutations of PTEN in patients with Bannayan-Riley-Ruvalcaba phenotype

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Germline PTEN mutations in Cowden syndrome-like families.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase

27 September 2017

1 reference

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A gene for familial juvenile polyposis maps to chromosome 18q21.1.

27 September 2017

1 reference

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Ras signalling and apoptosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Inherited mutations in PTEN that are associated with breast cancer, cowden disease, and juvenile polyposis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in BRCA1-negative cases.

27 September 2017

1 reference

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Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Phosphatidylinositol 3-kinase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Cowden syndrome (multiple hamartoma syndrome).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

VATER and hydrocephalus: distinct syndrome?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

PTEN does not modulate GLUT4 translocation in rat adipose cells under physiological conditions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E/CDK2 complexes

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Absence of PTEN/MMAC1 germ-line mutations in sporadic Bannayan-Riley-Ruvalcaba syndrome.

30 May 2018

1 reference

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Mutations in the SMAD4/DPC4 gene in juvenile polyposis

30 May 2018

1 reference

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Molecular classification of the inherited hamartoma polyposis syndromes: clearing the muddied waters

30 May 2018

1 reference

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Cowden disease. Report of a family and review

30 May 2018

1 reference

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Germline mutations in PTEN are present in Bannayan-Zonana syndrome

30 May 2018

1 reference

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Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma

30 May 2018

1 reference

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The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling

28 November 2018

1 reference

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PTEN mutations are uncommon in Proteus syndrome.

28 November 2018

1 reference

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Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

28 November 2018

1 reference

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Growth and gene expression profile analyses of endometrial cancer cells expressing exogenous PTEN.

28 November 2018

1 reference

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Absence of germline mutations in MINPP1, a phosphatase encoding gene centromeric of PTEN, in patients with Cowden and Bannayan-Riley-Ruvalcaba syndrome without germline PTEN mutations

28 November 2018

1 reference

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Genetic heterogeneity in familial juvenile polyposis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Variant manifestation of Cowden disease in Japan: hamartomatous polyposis of the digestive tract with mutation of the PTEN gene

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Germline PTEN mutation in a family with Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Localization of the gene for Cowden disease to chromosome 10q22–23

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=379112

Novel PTEN mutations in patients with Cowden disease: absence of clear genotype-phenotype correlations

28 November 2018

1 reference

12 December 2020

PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death

1 reference

12 December 2020

Balanced translocation of 10q and13q, including the PTEN gene, in a boy with a human chorionic gonadotropin-secreting tumor and the Bannayan-Riley-Ruvalcaba syndrome

1 reference

12 December 2020

Expression of the PTEN tumour suppressor protein during human development

1 reference

12 December 2020

Identification of a PTEN mutation in a family with Cowden syndrome and Bannayan-Zonana syndrome

1 reference

12 December 2020

Association of germline mutation in the PTEN tumour suppressor gene and Proteus and Proteus-like syndromes

1 reference

12 December 2020

Bannayan-Riley-Ruvalcaba syndrome

1 reference

12 December 2020

1 reference

12 December 2020

The Cowden syndrome: a clinical and genetic study in 21 patients

1 reference

12 December 2020

Hydrocephalus with features of VATER

1 reference

12 December 2020

Deletion of PTEN in a patient with Bannayan-Riley-Ruvalcaba syndrome suggests allelism with Cowden disease

1 reference

12 December 2020

Exclusion of PTEN and 10q22-24 as the susceptibility locus for juvenile polyposis syndrome

1 reference

12 December 2020

PTEN germ-line mutations in juvenile polyposis coli

1 reference

12 December 2020

Mechanisms and consequences of activation of protein kinase B/Akt

1 reference

12 December 2020

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1 reference

12 December 2020

Phospholipid signalling in the nucleus. Een DAG uit het leven van de inositide signalering in de nucleus

1 reference

12 December 2020

Phosphatidylinositol 3-Kinase in HL-60 Nuclei Is Bound to the Nuclear Matrix and Increases During Granulocytic Differentiation

1 reference

12 December 2020

Identifiers

DOI

10.1086/340026

1 reference

1 reference

1 reference

PubMed publication ID

11875759

1 reference