Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease (Q24621854)

Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model

Europe PubMed Central

title

Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease (English)

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Don W Cleveland

2

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author name string

Christian S Lobsiger

series ordinal

1

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language of work or name

English

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publication date

November 2007

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published in

Nature Neuroscience

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volume

10

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issue

11

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page(s)

1355-60

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cites work

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Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

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ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

30 May 2018

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Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport.

21 January 2018

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Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice.

28 November 2018

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Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

28 November 2018

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Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue

28 November 2018

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Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

28 November 2018

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SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity.

28 November 2018

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Polyglutamine-expanded ataxin-7 promotes non-cell-autonomous purkinje cell degeneration and displays proteolytic cleavage in ataxic transgenic mice.

28 November 2018

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Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

28 November 2018

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Impaired glutamate uptake in the R6 Huntington's disease transgenic mice.

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Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment.

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Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

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SCA1 transgenic mice: A model for neurodegeneration caused by an expanded CAG trinucleotide repeat

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12 December 2020

Increased cytotoxic potential of microglia from ALS-transgenic mice

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12 December 2020

The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS

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12 December 2020

Absence of tumor necrosis factor-alpha does not affect motor neuron disease caused by superoxide dismutase 1 mutations

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12 December 2020

Mouse model of multiple system atrophy alpha-synuclein expression in oligodendrocytes causes glial and neuronal degeneration

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12 December 2020

Coincident thresholds of mutant protein for paralytic disease and protein aggregation caused by restrictively expressed superoxide dismutase cDNA

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12 December 2020

Survival in a transgenic model of FALS is independent of iNOS expression

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12 December 2020

Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex

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12 December 2020

SCA7 mouse models show selective stabilization of mutant ataxin-7 and similar cellular responses in different neuronal cell types

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12 December 2020

Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration

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12 December 2020

Accumulation of SOD1 mutants in postnatal motoneurons does not cause motoneuron pathology or motoneuron disease

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12 December 2020

Identifiers

DOI

10.1038/NN1988

1 reference

Dimensions Publication ID

130621

1011164477

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130621

1 reference

1 reference

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