Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways (Q24621990)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20952383%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

title

Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways (English)

1 reference

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15 February 2020

0 references

1 reference

1

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15 February 2020

Olexander Korchynskyi

2

1 reference

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15 February 2020

Karien de Rooij

3

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15 February 2020

Aris Economides

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15 February 2020

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Clemens W G M Löwik

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15 February 2020

author name string

Stella E Weidauer

4

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15 February 2020

David J J de Gorter

5

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15 February 2020

Rutger L van Bezooijen

6

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15 February 2020

Sarah Hatsell

7

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15 February 2020

Thomas D Mueller

9

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15 February 2020

Peter ten Dijke

11

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15 February 2020

language of work or name

English

0 references

publication date

15 October 2010

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Journal of Biological Chemistry

15 February 2020

published in

1 reference

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15 February 2020

volume

285

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15 February 2020

page(s)

41614-41626

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15 February 2020

issue

53

1 reference

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Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal

15 February 2020

cites work

1 reference

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SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

7 April 2017

1 reference

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Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist

7 April 2017

1 reference

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Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

7 April 2017

1 reference

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Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density

7 April 2017

1 reference

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Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

7 April 2017

1 reference

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A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

7 April 2017

1 reference

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Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

7 April 2017

1 reference

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Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

7 April 2017

1 reference

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The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals

7 April 2017

1 reference

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Characterization of the Structural Features and Interactions of Sclerostin: MOLECULAR INSIGHT INTO A KEY REGULATOR OF Wnt-MEDIATED BONE FORMATION

7 April 2017

1 reference

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NMR structure of the Wnt modulator protein Sclerostin

7 April 2017

1 reference

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Control of bone mass and remodeling by PTH receptor signaling in osteocytes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009889

Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength

7 April 2017

1 reference

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Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009889

The association of GSK3 beta with E2F1 facilitates nerve growth factor-induced neural cell differentiation

7 April 2017

1 reference

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Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin

7 April 2017

1 reference

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BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis

7 April 2017

1 reference

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Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009889

Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009889

Smad transcription factors

7 April 2017

1 reference

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Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009889

Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis

7 April 2017

1 reference

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Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009889

Bone morphogenetic proteins

7 April 2017

1 reference

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Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation

7 April 2017

1 reference

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USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney

7 April 2017

1 reference

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Cbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST)

7 April 2017

1 reference

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Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling

7 April 2017

1 reference

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A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population

7 April 2017

1 reference

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Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

7 April 2017

1 reference

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High bone density due to a mutation in LDL-receptor-related protein 5

7 April 2017

1 reference

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Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter

7 April 2017

1 reference

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7 April 2017

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Specificity and versatility in tgf-beta signaling through Smads

7 April 2017

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Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors

7 April 2017

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7 April 2017

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BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009889

Osteocyte-derived sclerostin inhibits bone formation: its role in bone morphogenetic protein and Wnt signaling.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009889

Osteocytes, mechanosensing and Wnt signaling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009889

A rapid and sensitive bioassay to measure bone morphogenetic protein activity

27 September 2017

1 reference

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Osteocytes as dynamic multifunctional cells

27 September 2017

1 reference

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Mechanosensation and Transduction in Osteocytes

27 September 2017

1 reference

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Novel LRP5 missense mutation in a patient with a high bone mass phenotype results in decreased DKK1-mediated inhibition of Wnt signaling

27 September 2017

1 reference

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Bone morphogenetic proteins and their antagonists

27 September 2017

1 reference

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SOST is a target gene for PTH in bone

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009889

SOST/sclerostin, an osteocyte-derived negative regulator of bone formation

27 September 2017

1 reference

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Wnt signaling in disease and in development

27 September 2017

1 reference

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Wnt signaling in osteoblasts and bone diseases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009889

BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop

27 September 2017

1 reference

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Comparative Genomic Analysis of the Eight-Membered Ring Cystine Knot-Containing Bone Morphogenetic Protein Antagonists

27 September 2017

1 reference

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Wise, a context-dependent activator and inhibitor of Wnt signalling

27 September 2017

1 reference

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Bone morphogenetic proteins, their antagonists, and the skeleton

27 September 2017

1 reference

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Differentiation of murine preosteoblastic KS483 cells depends on autocrine bone morphogenetic protein signaling during all phases of osteoblast formation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009889

Osteocytes, strain detection, bone modeling and remodeling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009889

Function of osteocytes in bone--their role in mechanotransduction

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009889

Subcloning of three osteoblastic cell lines with distinct differentiation phenotypes from the mouse osteoblastic cell line KS-4.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009889

The syndromic status of sclerosteosis and van Buchem disease.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009889

Mechanics of increased support of weight by the hindlimbs in primates

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009889

The natural history of sclerosteosis

30 May 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.153890

The ubiquitin-proteasome system is a key component of the SUMO-2/3 cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.153890

Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.153890

BMP4 activation and secretion are negatively regulated by an intracellular gremlin-BMP4 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.153890

Smad1, beta-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.153890

Bone morphogenetic protein-7 protects human intervertebral disc cells in vitro from apoptosis.

21 January 2018

1 reference

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The L45 loop in type I receptors for TGF-beta family members is a critical determinant in specifying Smad isoform activation

21 January 2018

1 reference

12 December 2020

Balancing BMP Signaling through Integrated Inputs into the Smad1 Linker

1 reference

12 December 2020

Locomotory stresses in the limb bones of two small mammals: the ground squirrel and chipmunk

1 reference

12 December 2020

Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone

1 reference

12 December 2020

Effects of intermittent parathyroid hormone (PTH) administration on SOST mRNA and protein in rat bone

1 reference

12 December 2020

In vivo osteocyte death

1 reference

12 December 2020

Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction

1 reference

12 December 2020

Osteogenic protein-1 (OP-1) expression and processing in Chinese hamster ovary cells: isolation of a soluble complex containing the mature and pro-domains of OP-1

1 reference

12 December 2020

Cell fate specification and competence by Coco, a maternal BMP, TGFbeta and Wnt inhibitor

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.153890

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20952383%20AND%20SRC:MED&resulttype=core&format=json

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15 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7seppbkexzgzxlls6u33igzody

24 November 2022

mapped directly with Wikidata item

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20952383%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

2 references