Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling (Q24633992)

5

object named as

Richard B Gaynor

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author name string

Tohru Ishitani

1

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Giichi Takaesu

2

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Hiroshi Shibuya

4

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Richard B Gaynor

5

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Kunihiro Matsumoto

Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol

6

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language of work or name

English

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publication date

1 December 2003

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published in

The EMBO Journal

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volume

22

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issue

23

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page(s)

6277-88

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cites work

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Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway

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The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

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TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway

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Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

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Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2).

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TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling

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Gene profiling during neural induction in Xenopus laevis: regulation of BMP signaling by post-transcriptional mechanisms and TAB3, a novel TAK1-binding protein.

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