Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK (Q24644674)

1

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Smitha Antony

2

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Shalu Gupta

3

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Thomas S Dexheimer

4

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Christophe E Redon

5

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Susan Garfield

6

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Yosef Shiloh

Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks

7

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language of work or name

English

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publication date

2 December 2009

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published in

The EMBO Journal

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volume

28

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issue

23

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page(s)

3667-80

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cites work

1 reference

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Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK

7 April 2017

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Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair

7 April 2017

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Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?

7 April 2017

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Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1

7 April 2017

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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

7 April 2017

1 reference

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XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage

7 April 2017

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Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

7 April 2017

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Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)

7 April 2017

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Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

7 April 2017

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The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily

7 April 2017

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Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

7 April 2017

1 reference

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

7 April 2017

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Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells

7 April 2017

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Cellular roles of dna topoisomerases: a molecular perspective

7 April 2017

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DNA topoisomerases: structure, function, and mechanism

7 April 2017

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Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks

7 April 2017

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Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage

7 April 2017

1 reference

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Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes

7 April 2017

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TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo

7 April 2017

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TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II

7 April 2017

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The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks

7 April 2017

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

7 April 2017

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Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy

7 April 2017

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ATR: an essential regulator of genome integrity

7 April 2017

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Single-strand break repair and genetic disease

7 April 2017

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Topoisomerase I inhibitors: camptothecins and beyond

7 April 2017

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

7 April 2017

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In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation

7 April 2017

1 reference

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PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro

27 September 2017

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Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy

27 September 2017

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XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks

27 September 2017

1 reference

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Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

27 September 2017

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DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?

27 September 2017

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XRCC1 and PCNA are loading platforms with distinct kinetic properties and different capacities to respond to multiple DNA lesions

27 September 2017

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The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses

27 September 2017

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Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes

27 September 2017

1 reference

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Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks

27 September 2017

1 reference

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Repair of topoisomerase I-mediated DNA damage

27 September 2017

1 reference

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Surviving the breakup: the DNA damage checkpoint.

27 September 2017

1 reference

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Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage

27 September 2017

1 reference

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Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790489

SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity

27 September 2017

1 reference

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Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries

27 September 2017

1 reference

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Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790489

Ataxia-telangiectasia, an evolving phenotype

27 September 2017

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27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790489

XRCC1 and DNA strand break repair

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790489

Mechanism of action of camptothecin

27 September 2017

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Topoisomerase I-mediated DNA damage

27 September 2017

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Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff

27 September 2017

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Utilization of oriented peptide libraries to identify substrate motifs selected by ATM.

27 September 2017

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Roles of replication protein A and DNA-dependent protein kinase in the regulation of DNA replication following DNA damage

27 September 2017

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Rejoining kinetics of DNA single- and double-strand breaks in normal and DNA ligase-deficient cells after exposure to ultraviolet C and gamma radiation: an evaluation of ligating activities involved in different DNA repair processes

27 September 2017

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Processing of topoisomerase I cleavable complexes into DNA damage by transcription.

27 September 2017

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A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases

27 September 2017

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Protein-linked DNA strand breaks induced in mammalian cells by camptothecin, an inhibitor of topoisomerase I.

27 September 2017

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Histone H1 functions as a stimulatory factor in backup pathways of NHEJ

27 September 2017

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Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

30 May 2018

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CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins.

21 January 2018

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Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions

21 January 2018

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Pathways for repair of topoisomerase I covalent complexes in Saccharomyces cerevisiae

21 January 2018

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Base excision repair proteins are required for integrin-mediated suppression of bleomycin-induced DNA breakage in murine lung endothelial cells.

21 January 2018

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The ATM-mediated DNA-damage response: taking shape.

21 January 2018

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Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex

21 January 2018

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Chk2 molecular interaction map and rationale for Chk2 inhibitors

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19851285

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19851285

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Interaction between replication forks and topoisomerase I-DNA cleavable complexes: studies in a cell-free SV40 DNA replication system

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19851285

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/EMBOJ.2009.302

1 reference

1680173

1680173

1 reference

1 reference

1 reference