Structural determinants of drugs acting on the Nav1.8 channel (Q24644825)

2

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Shahnaz P Yusaf

3

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Jeff J Clare

4

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Dennis Wray

Journal of Biological Chemistry

5

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language of work or name

English

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publication date

17 April 2009

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published in

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volume

284

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issue

16

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page(s)

10523-36

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cites work

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7 April 2017

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An SCN9A channelopathy causes congenital inability to experience pain

7 April 2017

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7 April 2017

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Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

7 April 2017

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Nomenclature of voltage-gated sodium channels

7 April 2017

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From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels

21 January 2018

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Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels

7 April 2017

1 reference

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Backbone-dependent rotamer library for proteins. Application to side-chain prediction

7 April 2017

1 reference

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A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons

7 April 2017

1 reference

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Voltage-gated sodium channel blockers for the treatment of neuropathic pain

7 April 2017

1 reference

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A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.

27 September 2017

1 reference

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Small interfering RNA-mediated selective knockdown of Na(V)1.8 tetrodotoxin-resistant sodium channel reverses mechanical allodynia in neuropathic rats

27 September 2017

1 reference

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Use-dependent block by lidocaine but not amitriptyline is more pronounced in tetrodotoxin (TTX)-Resistant Nav1.8 than in TTX-sensitive Na+ channels

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667739

Interactions of local anesthetics with voltage-gated Na+ channels

27 September 2017

1 reference

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Stable Expression and Characterization of Human PN1 and PN3 Sodium Channels

27 September 2017

1 reference

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Molecular mechanisms of gating and drug block of sodium channels

27 September 2017

1 reference

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The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667739

A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain

27 September 2017

1 reference

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Transient and stable gene expression in mammalian cells transduced with a recombinant baculovirus vector

27 September 2017

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A mutation in segment I-S6 alters slow inactivation of sodium channels

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667739

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667739

Molecular basis of charge movement in voltage-gated sodium channels

27 September 2017

1 reference

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Differential properties of tetrodotoxin-sensitive and tetrodotoxin- resistant sodium channels in rat dorsal root ganglion neurons

27 September 2017

1 reference

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Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specific to sensory neurons.

30 May 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807569200

A role for the TTX-resistant sodium channel Nav 1.8 in NGF-induced hyperalgesia, but not neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807569200

Involvement of the TTX-resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post-operative, pain states.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807569200

Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807569200

Differential interactions of lamotrigine and related drugs with transmembrane segment IVS6 of voltage-gated sodium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807569200

Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel alpha subunit in voltage-dependent gating and drug block.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807569200

CHARMM: A program for macromolecular energy, minimization, and dynamics calculations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807569200

Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807569200

Altered gating and local anesthetic block mediated by residues in the I-S6 and II-S6 transmembrane segments of voltage-dependent Na+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807569200

Slow sodium channel inactivation and use-dependent block modulated by the same domain IV S6 residue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807569200

Point mutations at L1280 in Nav1.4 channel D3-S6 modulate binding affinity and stereoselectivity of bupivacaine enantiomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807569200

Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807569200

The Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807569200

Deficits in visceral pain and referred hyperalgesia in Nav1.8 (SNS/PN3)-null mice.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667739

Point mutations at N434 in D1-S6 of mu1 Na(+) channels modulate binding affinity and stereoselectivity of local anesthetic enantiomers.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667739

A molecular basis for the different local anesthetic affinities of resting versus open and inactivated states of the sodium channel.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667739

Slow binding of phenytoin to inactivated sodium channels in rat hippocampal neurons.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2667739

A critical role for transmembrane segment IVS6 of the sodium channel alpha subunit in fast inactivation

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19233853

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A common anticonvulsant binding site for phenytoin, carbamazepine, and lamotrigine in neuronal Na+ channels

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19233853