Interactions of local anesthetics with voltage-gated Na+ channels (Q34382262)

1 August 2017

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title

Interactions of local anesthetics with voltage-gated Na+ channels (English)

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1 August 2017

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Nau C

1

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1 August 2017

Wang GK

series ordinal

2

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1 August 2017

publication date

1 September 2004

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1 August 2017

number of pages

8

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Journal of Membrane Biology

inferred from page(s)

published in

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1 August 2017

volume

201

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1 August 2017

issue

1

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1 August 2017

page(s)

1-8

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Lidocaine block of LQT-3 mutant human Na+ channels

1 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS00232-004-0702-Y

On the molecular nature of the lidocaine receptor of cardiac Na+ channels. Modification of block by alterations in the alpha-subunit III-IV interdomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-004-0702-Y

A quantitative description of membrane current and its application to conduction and excitation in nerve

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00232-004-0702-Y

Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-004-0702-Y

Local anaesthetics transiently block currents through single acetylcholine-receptor channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00232-004-0702-Y

A critical role for transmembrane segment IVS6 of the sodium channel alpha subunit in fast inactivation

21 January 2018

1 reference

12 December 2020

The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4.

1 reference

12 December 2020

A structural rearrangement in the sodium channel pore linked to slow inactivation and use dependence

1 reference

12 December 2020

The role of inactivation in open-channel block of the sodium channel: studies with inactivation-deficient mutant channels

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12 December 2020

Altered stereoselectivity of cocaine and bupivacaine isomers in normal and batrachotoxin-modified Na+ channels

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12 December 2020

Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics

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12 December 2020

Altered gating and local anesthetic block mediated by residues in the I-S6 and II-S6 transmembrane segments of voltage-dependent Na+ channels

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12 December 2020

Residue-specific effects on slow inactivation at V787 in D2-S6 of Na(v)1.4 sodium channels

1 reference

12 December 2020

A revised view of cardiac sodium channel "blockade" in the long-QT syndrome

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12 December 2020

Structural parts involved in activation and inactivation of the sodium channel

1 reference

12 December 2020

Inhibition of sodium currents by local anesthetics in chloramine-T-treated squid axons. The role of channel activation

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12 December 2020

Point mutations at N434 in D1-S6 of mu1 Na(+) channels modulate binding affinity and stereoselectivity of local anesthetic enantiomers.

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12 December 2020

Inhibition of mammalian Gq protein function by local anesthetics

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12 December 2020

Role of domain 4 in sodium channel slow inactivation

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12 December 2020

A reinterpretation of mammalian sodium channel gating based on single channel recording

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12 December 2020

Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel alpha subunit in voltage-dependent gating and drug block.

1 reference

12 December 2020

International Union of Pharmacology. XXXIX. Compendium of voltage-gated ion channels: sodium channels.

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12 December 2020

A mutation in segment IVS6 disrupts fast inactivation of sodium channels

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12 December 2020

Voltage sensors in domains III and IV, but not I and II, are immobilized by Na+ channel fast inactivation

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12 December 2020

Neurotoxins that Act on Voltage-Sensitive Sodium Channels in Excitable Membranes

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12 December 2020

Sodium channel activation gating is affected by substitutions of voltage sensor positive charges in all four domains

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12 December 2020

Point mutations at L1280 in Nav1.4 channel D3-S6 modulate binding affinity and stereoselectivity of bupivacaine enantiomers

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12 December 2020

Local anesthetic block of batrachotoxin-resistant muscle Na+ channels

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12 December 2020

Interaction of batrachotoxin with the local anesthetic receptor site in transmembrane segment IVS6 of the voltage-gated sodium channel

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12 December 2020

Permeation of large tetra-alkylammonium cations through mutant and wild-type voltage-gated sodium channels as revealed by relief of block at high voltage

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12 December 2020

Interaction of polypeptide neurotoxins with a receptor site associated with voltage-sensitive sodium channels

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12 December 2020

Restoration of inactivation and block of open sodium channels by an inactivation gate peptide

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12 December 2020

Sodium channel selectivity filter regulates antiarrhythmic drug binding

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12 December 2020

The open pore conformation of potassium channels

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12 December 2020

Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers

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12 December 2020

Residues in Na(+) channel D3-S6 segment modulate both batrachotoxin and local anesthetic affinities

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12 December 2020

Molecular basis of charge movement in voltage-gated sodium channels

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12 December 2020

A mutation in segment I-S6 alters slow inactivation of sodium channels

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12 December 2020

Construction of a high-affinity receptor site for dihydropyridine agonists and antagonists by single amino acid substitutions in a non-L-type Ca2+ channel

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12 December 2020

A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation

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12 December 2020

Mexiletine block of wild‐type and inactivation‐deficient human skeletal muscle hNav1.4 Na+ channels

1 reference

12 December 2020

A critical role for the S4-S5 intracellular loop in domain IV of the sodium channel alpha-subunit in fast inactivation

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12 December 2020

From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels

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12 December 2020

Molecular determinants of state-dependent block of Na+ channels by local anesthetics

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12 December 2020

Evidence for voltage-dependent S4 movement in sodium channels

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12 December 2020

Local anesthetics as effectors of allosteric gating. Lidocaine effects on inactivation-deficient rat skeletal muscle Na channels

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12 December 2020

Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors

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12 December 2020

State-dependent block of wild-type and inactivation-deficient Na+ channels by flecainide

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12 December 2020

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction

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12 December 2020

Batrachotoxin-resistant Na+ channels derived from point mutations in transmembrane segment D4-S6

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12 December 2020

Block of wild-type and inactivation-deficient cardiac sodium channels IFM/QQQ stably expressed in mammalian cells

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12 December 2020

Pharmacological targeting of long QT mutant sodium channels

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12 December 2020

Point mutations in segment I-S6 render voltage-gated Na+ channels resistant to batrachotoxin

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12 December 2020

Lysine point mutations in Na+ channel D4-S6 reduce inactivated channel block by local anesthetics

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12 December 2020

Identification of an intracellular peptide segment involved in sodium channel inactivation

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12 December 2020

Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit.

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12 December 2020

The position of the fast-inactivation gate during lidocaine block of voltage-gated Na+ channels

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12 December 2020

Molecular dynamics of the sodium channel pore vary with gating: interactions between P-segment motions and inactivation.

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12 December 2020

Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2

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12 December 2020

A single residue differentiates between human cardiac and skeletal muscle Na+ channel slow inactivation

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12 December 2020

Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels

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12 December 2020

A molecular basis for the different local anesthetic affinities of resting versus open and inactivated states of the sodium channel.

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12 December 2020

Rapid and slow voltage-dependent conformational changes in segment IVS6 of voltage-gated Na(+) channels

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12 December 2020

Voltage-gated sodium channels as primary targets of diverse lipid-soluble neurotoxins

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12 December 2020

Disparate role of Na(+) channel D2-S6 residues in batrachotoxin and local anesthetic action

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12 December 2020

A point mutation in domain 4-segment 6 of the skeletal muscle sodium channel produces an atypical inactivation state

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12 December 2020

Negatively charged residues adjacent to IFM motif in the DIII–DIV linker of hNaV1.4 differentially affect slow inactivation

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12 December 2020

Interaction between the sodium channel inactivation linker and domain III S4-S5.

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12 December 2020

Levels of batrachotoxin and lack of sensitivity to its action in poison-dart frogs (Phyllobates)

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12 December 2020

Structural rearrangements underlying K+-channel activation gating

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12 December 2020

10.1007/S00232-004-0702-Y

Identifiers

DOI

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Dimensions Publication ID

1 August 2017

1035450700

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