Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation (Q24648213)

1

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Hugo A Acosta-Jaquez

2

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Bilgen Ekim

4

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Ghada A Soliman

5

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Audrey Carriere

6

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Philippe P Roux

7

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Bryan A Ballif

8

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Diane C Fingar

Journal of Biological Chemistry

9

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language of work or name

English

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publication date

1 January 2010

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published in

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volume

285

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issue

1

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page(s)

80-94

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cites work

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

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The TSC1-TSC2 complex: a molecular switchboard controlling cell growth

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

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The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

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Identification of Protor as a novel Rictor-binding component of mTOR complex-2

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

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Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

7 April 2017

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Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

7 April 2017

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Large-scale characterization of HeLa cell nuclear phosphoproteins

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

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mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

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Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

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Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

7 April 2017

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

7 April 2017

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

7 April 2017

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A probability-based approach for high-throughput protein phosphorylation analysis and site localization

7 April 2017

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TOR signaling in growth and metabolism

7 April 2017

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TSC2 mediates cellular energy response to control cell growth and survival

7 April 2017

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Global, in vivo, and site-specific phosphorylation dynamics in signaling networks

7 April 2017

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GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

7 April 2017

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

7 April 2017

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Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation

7 April 2017

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Defining the role of mTOR in cancer

7 April 2017

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PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding

7 April 2017

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Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations

7 April 2017

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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

7 April 2017

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mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

7 April 2017

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mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

7 April 2017

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Rheb binds and regulates the mTOR kinase

7 April 2017

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Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

7 April 2017

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Phosphoproteomic analysis of the developing mouse brain

7 April 2017

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TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

7 April 2017

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Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor

7 April 2017

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The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

7 April 2017

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Hierarchical phosphorylation of the translation inhibitor 4E-BP1

7 April 2017

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

7 April 2017

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mTOR signaling at a glance

7 April 2017

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Molecular mechanisms of mTOR-mediated translational control

7 April 2017

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Regulation of TORC1 by Rag GTPases in nutrient response

7 April 2017

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

7 April 2017

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Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

7 April 2017

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Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

7 April 2017

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Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth.

7 April 2017

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Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR.

28 September 2017

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mTOR and the control of whole body metabolism

28 September 2017

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28 September 2017

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Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor

28 September 2017

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28 September 2017

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Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation

28 September 2017

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Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.

28 September 2017

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Quantitative analysis of synaptic phosphorylation and protein expression

28 September 2017

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mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer

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28 September 2017

The two TORCs and Akt.

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Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways

28 September 2017

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mTOR, translational control and human disease.

28 September 2017

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Restraining PI3K: mTOR signalling goes back to the membrane.

28 September 2017

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28 September 2017

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GSK3 takes centre stage more than 20 years after its discovery

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Insulin regulates transcription of the CCAAT/enhancer binding protein (C/EBP) alpha, beta, and delta genes in fully-differentiated 3T3-L1 adipocytes

28 September 2017

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Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes.

28 September 2017

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mTOR signaling: RAG GTPases transmit the amino acid signal

28 September 2017

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PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.

21 January 2018

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mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

21 January 2018

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Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

21 January 2018

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Regulation of translation initiation by FRAP/mTOR

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Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle

21 January 2018

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