Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells (Q24651232)

Nicholas P Restifo

13

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Chrystal M Paulos

11

Chrystal M Paulos

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Claudia Wrzesinski

7

Claudia Wrzesinski

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Christian S Hinrichs

5

Christian S Hinrichs

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Lydie Cassard

9

Lydie Cassard

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Pawel Muranski

12

Pawel Muranski

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Luca Gattinoni

1

Luca Gattinoni

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author name string

Xiao-Song Zhong

2

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Yun Ji

4

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Zhiya Yu

6

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Andrea Boni

8

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Lindsay M Garvin

Cancer regression in patients after transfer of genetically engineered lymphocytes

10

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language of work or name

English

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publication date

July 2009

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published in

Nature Medicine

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volume

15

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issue

7

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page(s)

808-13

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cites work

1 reference

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Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells

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Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3

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Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin

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Wnt proteins are lipid-modified and can act as stem cell growth factors

7 April 2017

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Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo.

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Rapid culling of the CD4+ T cell repertoire in the transition from effector to memory

28 September 2017

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IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy

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Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection

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Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cells

28 September 2017

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CD8+ T-cell memory in tumor immunology and immunotherapy

28 September 2017

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Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

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Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.

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Synthetic small molecules that control stem cell fate

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Homeostatic T cell proliferation: how far can T cells be activated to self-ligands?

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12 December 2020

Critical involvement of Tcf-1 in expansion of thymocytes

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Identifiers

DOI

10.1038/NM.1982

1 reference

Dimensions Publication ID

506347

1011471951

0 references

506347

1 reference

1 reference

1 reference