Doubly truncated FosB isoform (Delta2DeltaFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP-1 activity (Q24653375)

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English	Doubly truncated FosB isoform (Delta2DeltaFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP-1 activity	scientific article

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6 January 2020

Doubly truncated FosB isoform (Delta2DeltaFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP-1 activity (English)

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6 January 2020

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6 January 2020

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6 January 2020

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George Sabatakos

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6 January 2020

Meilin Wu

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6 January 2020

Lynn Neff

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6 January 2020

Riccardo Chiusaroli

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6 January 2020

William M Philbrick

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6 January 2020

Roland Baron

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1 May 2008

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6 January 2020

Journal of Bone and Mineral Research

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6 January 2020

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6 January 2020

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6 January 2020

584-595

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6 January 2020

Signal transduction of bone morphogenetic protein receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2674536

7 April 2017

Smads bind directly to the Jun family of AP-1 transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2674536

7 April 2017

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2674536

7 April 2017

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2674536

7 April 2017

Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia

1 reference

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7 April 2017

A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity

1 reference

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7 April 2017

Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells

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7 April 2017

Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects

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7 April 2017

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

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7 April 2017

Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members

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7 April 2017

Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation

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7 April 2017

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

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7 April 2017

AP-1 as a regulator of cell life and death

1 reference

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7 April 2017

AP-1 function and regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2674536

7 April 2017

Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee

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7 April 2017

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

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7 April 2017

https://pubmed.ncbi.nlm.nih.gov/18433296

12 December 2020

based on heuristic

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CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2674536

28 September 2017

Fos/AP-1 proteins in bone and the immune system

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28 September 2017

A CCAAT/enhancer binding protein beta isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes

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28 September 2017

BMP signaling in skeletal development

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28 September 2017

DeltaFosB induces osteosclerosis and decreases adipogenesis by two independent cell-autonomous mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2674536

28 September 2017

Biology of the basic multicellular unit and the pathophysiology of osteoporosis

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28 September 2017

DeltaFosB, but not FosB, induces delayed apoptosis independent of cell proliferation in the Rat1a embryo cell line.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2674536

28 September 2017

Bone morphogenetic proteins, their antagonists, and the skeleton

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28 September 2017

The increased bone mass in deltaFosB transgenic mice is independent of circulating leptin levels.

1 reference

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28 September 2017

Functions of AP1 (Fos/Jun) in bone development

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28 September 2017

Epstein-Barr virus BZLF1 gene is activated by transforming growth factor-beta through cooperativity of Smads and c-Jun/c-Fos proteins

1 reference

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28 September 2017

Targeted and nontargeted bone remodeling: relationship to basic multicellular unit origination and progression

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28 September 2017

Bone homeostasis in growth hormone receptor-null mice is restored by IGF-I but independent of Stat5.

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28 September 2017

Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis.

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28 September 2017

Critical role of Smads and AP-1 complex in transforming growth factor-beta -dependent apoptosis

1 reference

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28 September 2017

Positive and negative regulation of TGF-beta signaling

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28 September 2017

Role of the CCAAT enhancer binding proteins (C/EBPs) in adipocyte differentiation

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28 September 2017

Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine

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28 September 2017

Induction of Smad6 mRNA by bone morphogenetic proteins

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28 September 2017

Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads

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28 September 2017

Smad1 and smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts

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28 September 2017

Transcriptional activation and transformation by FosB protein require phosphorylation of the carboxyl-terminal activation domain

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28 September 2017

A defect in nurturing in mice lacking the immediate early gene fosB.

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28 September 2017

Proto-oncogene FosB: the amino terminus encodes a regulatory function required for transformation

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28 September 2017

An autonomous N-terminal transactivation domain in Fos protein plays a crucial role in transformation

1 reference

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28 September 2017

A C-terminal domain in FosB, absent in FosB/SF and Fra-1, which is able to interact with the TATA binding protein, is required for altered cell growth.

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28 September 2017

A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples.

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28 September 2017

A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice

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28 September 2017

Both products of the fosB gene, FosB and its short form, FosB/SF, are transcriptional activators in fibroblasts

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28 September 2017

An alternative spliced form of FosB is a negative regulator of transcriptional activation and transformation by Fos proteins

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28 September 2017

Phosphorylation of c-Fos at the C-terminus enhances its transforming activity.

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28 September 2017

Notch 1 impairs osteoblastic cell differentiation

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30 May 2018

Transgenic animals with inducible, targeted gene expression in brain

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30 May 2018

Chronic Fos-related antigens: stable variants of deltaFosB induced in brain by chronic treatments

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30 May 2018

The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controlling [correction of controling] dorsoventral patterning of Xenopus mesoderm

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30 May 2018

Expression of FosB during mouse development: normal development of FosB knockout mice.

1 reference

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30 May 2018

Osteoblasts are target cells for transformation in c-fos transgenic mice

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30 May 2018

Multiple regions of v-Fos protein involved in the activation of AP1-dependent transcription: is trans-activation crucial for transformation?

1 reference

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30 May 2018

Alternative splicing of fosB transcripts results in differentially expressed mRNAs encoding functionally antagonistic proteins

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30 May 2018

Transformation by FosB requires a trans-activation domain missing in FosB2 that can be substituted by heterologous activation domains

1 reference

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30 May 2018

Transcriptional induction of FosB/DeltaFosB gene by mechanical stress in osteoblasts

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28 November 2018

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28 November 2018

Regulating DeltaFosB expression in adult Tet-Off-DeltaFosB transgenic mice alters bone formation and bone mass

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28 November 2018

CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression.

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28 November 2018

Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1

1 reference

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28 November 2018

Bone and haematopoietic defects in mice lacking c-fos

1 reference

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28 November 2018

Determination of the capacity for proliferation and differentiation of osteoprogenitor cells in the presence and absence of dexamethasone

1 reference

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12 December 2020

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Pleiotropic effects of a null mutation in the c-fos proto-oncogene

1 reference

https://pubmed.ncbi.nlm.nih.gov/18433296

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1359/JBMR.080110

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6 January 2020

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Europe PubMed Central

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6 January 2020

PubMed publication ID

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Europe PubMed Central

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6 January 2020

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