Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures (Q24655640)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19430461%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

title

Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures (English)

1 reference

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27 January 2020

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0 references

2

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27 January 2020

Da-Neng Wang

6

1 reference

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27 January 2020

author name string

Zheng Zhou

1

1 reference

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27 January 2020

Nathan K Karpowich

3

1 reference

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27 January 2020

Christopher J Law

4

1 reference

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27 January 2020

Maarten E A Reith

5

1 reference

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27 January 2020

language of work or name

English

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publication date

10 May 2009

1 reference

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Nature Structural & Molecular Biology

27 January 2020

published in

1 reference

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27 January 2020

volume

16

1 reference

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27 January 2020

issue

6

1 reference

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27 January 2020

page(s)

652-657

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Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition

27 January 2020

cites work

1 reference

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LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake

7 April 2017

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Population pharmacokinetic modelling of NS2330 (tesofensine) and its major metabolite in patients with Alzheimer's disease

7 April 2017

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Neurotransmitter transporters and their impact on the development of psychopharmacology

7 April 2017

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Plasma membrane monoamine transporters: structure, regulation and function

7 April 2017

1 reference

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Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation

7 April 2017

1 reference

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A competitive inhibitor traps LeuT in an open-to-out conformation

7 April 2017

1 reference

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Fluorine in pharmaceuticals: looking beyond intuition

7 April 2017

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Antidepressant binding site in a bacterial homologue of neurotransmitter transporters

7 April 2017

1 reference

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Coot: model-building tools for molecular graphics

7 April 2017

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The CCP4 suite: programs for protein crystallography

7 April 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

7 April 2017

2 references

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7 April 2017

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Antidepressant-like actions of DOV 21,947: a "triple" reuptake inhibitor

22 April 2017

1 reference

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The monoamine reuptake blocker brasofensine reverses akinesia without dyskinesia in MPTP-treated and levodopa-primed common marmosets

7 April 2017

1 reference

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Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine

7 April 2017

1 reference

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Neurochemical neutralization of methamphetamine with high-affinity nonselective inhibitors of biogenic amine transporters: a pharmacological strategy for treating stimulant abuse

7 April 2017

1 reference

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Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding

7 April 2017

2 references

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7 April 2017

Pharmacological profile of antidepressants and related compounds at human monoamine transporters

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758934

Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication

7 April 2017

1 reference

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Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters

7 April 2017

1 reference

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From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: synthesis and structure-activity relationship studies.

7 April 2017

1 reference

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Salt-bridge dynamics control substrate-induced conformational change in the membrane transporter GlpT.

28 September 2017

1 reference

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Sodium-coupled neurotransmitter transporters

28 September 2017

1 reference

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Mechanism of chloride interaction with neurotransmitter:sodium symporters.

28 September 2017

1 reference

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Identification of a chloride ion binding site in Na+/Cl -dependent transporters.

28 September 2017

1 reference

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Monitoring the function of membrane transport proteins in detergent-solubilized form

28 September 2017

1 reference

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Getting the message across: a recent transporter structure shows the way.

28 September 2017

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Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants

28 September 2017

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Aspartate 345 of the dopamine transporter is critical for conformational changes in substrate translocation and cocaine binding

28 September 2017

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Functional characterization of cysteine residues in GlpT, the glycerol 3-phosphate transporter of Escherichia coli

28 September 2017

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Characterization of a functional bacterial homologue of sodium-dependent neurotransmitter transporters

28 September 2017

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Characteristics of drug interactions with recombinant biogenic amine transporters expressed in the same cell type

28 September 2017

1 reference

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Cloning and expression of the mouse serotonin transporter

28 September 2017

1 reference

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Third-generation antidepressants

28 September 2017

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Development of antidepressant drugs. Fluoxetine (Prozac) and other selective serotonin uptake inhibitors.

28 September 2017

1 reference

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Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins

28 September 2017

1 reference

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Molecular structure of fluoxetine hydrochloride, a highly selective serotonin-uptake inhibitor.

28 September 2017

1 reference

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Interactions of antidepressants with the serotonin transporter: a contemporary molecular analysis.

30 May 2018

1 reference

The absolute configuration of sertraline (Zoloft) hydrochloride

21 January 2018

1 reference

High- and low-affinity binding of S-citalopram to the human serotonin transporter mutated at 20 putatively important amino acid positions

21 January 2018

1 reference

The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site

21 January 2018

1 reference

Structure and localisation of drug binding sites on neurotransmitter transporters.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758934

Processing of X-ray diffraction data collected in oscillation mode

28 November 2018

1 reference

Identification of a single amino acid, phenylalanine 586, that is responsible for high affinity interactions of tricyclic antidepressants with the human serotonin transporter

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19430461

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Sibutramine: a novel anti-obesity drug. A review of the pharmacological evidence to differentiate it from d-amphetamine and d-fenfluramine

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19430461

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.1602

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19430461%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

27 January 2020

1022615708

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19430461%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19430461%20AND%20SRC:MED&resulttype=core&format=json