Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention (Q24657569)

The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress

Europe PubMed Central

title

Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention (English)

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author name string

Ka Lung Cheung

series ordinal

1

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Ah-Ng Kong

series ordinal

2

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language of work or name

English

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publication date

March 2010

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published in

The AAPS Journal

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volume

12

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issue

1

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page(s)

87-97

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cites work

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Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response

7 April 2017

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Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation

28 September 2017

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Regulation of estrogen receptor alpha expression in human breast cancer cells by sulforaphane

28 September 2017

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Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis

28 September 2017

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PEITC induces G1 cell cycle arrest on HT-29 cells through the activation of p38 MAPK signaling pathway

28 September 2017

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28 September 2017

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Sulforaphane suppresses lipopolysaccharide-induced cyclooxygenase-2 (COX-2) expression through the modulation of multiple targets in COX-2 gene promoter

28 September 2017

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Biphasic modulation of cell proliferation by sulforaphane at physiologically relevant exposure times in a human colon cancer cell line

28 September 2017

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Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3.

28 September 2017

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Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1.

28 September 2017

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D,L-Sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and Apaf-1.

28 September 2017

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Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray

28 September 2017

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Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells

28 September 2017

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Modest induction of phase 2 enzyme activity in the F-344 rat prostate

28 September 2017

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Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5.

28 September 2017

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Chemopreventive functions of isothiocyanates

28 September 2017

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Time-dependent modulation of thioredoxin reductase activity might contribute to sulforaphane-mediated inhibition of NF-kappaB binding to DNA.

28 September 2017

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Modulation of xenobiotic metabolising enzymes by anticarcinogens -- focus on glutathione S-transferases and their role as targets of dietary chemoprevention in colorectal carcinogenesis

28 September 2017

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Dietary cancer-chemopreventive compounds: from signaling and gene expression to pharmacological effects

28 September 2017

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Beta-phenylethyl and 8-methylsulphinyloctyl isothiocyanates, constituents of watercress, suppress LPS induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages.

28 September 2017

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The glucosinolate-myrosinase system in an ecological and evolutionary context

28 September 2017

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Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811646

Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species.

28 September 2017

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28 September 2017

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Mechanism of oxidation reactions catalyzed by cytochrome p450 enzymes.

28 September 2017

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Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells.

28 September 2017

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Detoxifying cancer causing agents to prevent cancer

28 September 2017

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The role of oxidative stress in carcinogenesis

28 September 2017

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Selected isothiocyanates rapidly induce growth inhibition of cancer cells.

28 September 2017

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Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human HepG2 cells and hepatocytes

28 September 2017

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Differential responses from seven mammalian cell lines to the treatments of detoxifying enzyme inducers.

28 September 2017

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Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes

28 September 2017

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Apoptosis-based therapies

28 September 2017

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Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE).

28 September 2017

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Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms.

28 September 2017

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Chemoprevention by inducers of carcinogen detoxication enzymes

28 September 2017

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Cancer prevention: recent progress and future opportunities.

28 September 2017

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Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids)

28 September 2017

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Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts.

28 September 2017

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In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat.

30 May 2018

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Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase

30 May 2018

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Comparison of the bioactivity of two glucoraphanin hydrolysis products found in broccoli, sulforaphane and sulforaphane nitrile

30 May 2018

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30 May 2018

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Inhibition of Chemical Carcinogen-Induced Pulmonary Neoplasia by Butylated Hydroxyanisole

30 May 2018

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Quantitation of human uptake of the anticarcinogen phenethyl isothiocyanate after a watercress meal

30 May 2018

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Binding to protein by isothiocyanates: a potential mechanism for apoptosis induction in human non small lung cancer cells

30 May 2018

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Tissue differences in the modulation of rat cytochromes P450 and phase II conjugation systems by dietary doses of phenethyl isothiocyanate

28 November 2018

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Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway

28 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811646

De-repression of the p21 promoter in prostate cancer cells by an isothiocyanate via inhibition of HDACs and c-Myc

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811646

Serotonin receptors, novel targets of sulforaphane identified by proteomic analysis in Caco-2 cells

28 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811646

Cell-cycle specificity of sulforaphane-mediated apoptosis in Jurkat T-leukemia cells.

28 November 2018

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Modulating testosterone stimulated prostate growth by phenethyl isothiocyanate via Sp1 and androgen receptor down-regulation.

28 November 2018

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Sulforaphane inhibits osteoclastogenesis by inhibiting nuclear factor-kappaB.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811646

Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811646

ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811646

Pharmacokinetics of dietary phenethyl isothiocyanate in rats

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811646

Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811646

A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811646

Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811646

Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811646

Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811646

Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds

28 November 2018

1 reference

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Effect of dietary constituents with chemopreventive potential on adduct formation of a low dose of the heterocyclic amines PhIP and IQ and phase II hepatic enzymes

28 November 2018

1 reference

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Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC)

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811646

The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811646

Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811646

Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811646

Potent induction of phase 2 enzymes in human prostate cells by sulforaphane

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811646

Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811646

Dietary isothiocyanates inhibit Caco-2 cell proliferation and induce G2/M phase cell cycle arrest, DNA damage, and G2/M checkpoint activation

28 November 2018

1 reference

12 December 2020

Chemoprevention of cancer

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12 December 2020

Isothiocyanates inhibit cell cycle progression of HeLa cells at G2/M phase

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12 December 2020

Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes

1 reference

12 December 2020

Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2

1 reference

12 December 2020

Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable

1 reference

12 December 2020

10.1208/S12248-009-9162-8

Identifiers

DOI

1 reference

Dimensions Publication ID

1217527

1000918860

0 references

1217527

1 reference

1 reference

1 reference