The cancer chemopreventive actions of phytochemicals derived from glucosinolates (Q28279051)

European Journal of Nutrition

Europe PubMed Central

title

The cancer chemopreventive actions of phytochemicals derived from glucosinolates (English)

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Michael O Kelleher

2

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Ian Eggleston

object named as

Ian M Eggleston

series ordinal

3

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John D. Hayes

object named as

John D Hayes

series ordinal

1

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language of work or name

English

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publication date

May 2008

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published in

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volume

47 Suppl 2

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page(s)

73-88

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exact match

https://scigraph.springernature.com/pub.10.1007/s00394-008-2009-8

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cites work

Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.

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Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00394-008-2009-8

Raw versus cooked vegetables and cancer risk.

21 January 2018

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12 December 2020

Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells.

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12 December 2020

Development of isothiocyanate-enriched broccoli, and its enhanced ability to induce phase 2 detoxification enzymes in mammalian cells.

1 reference

12 December 2020

Comparison of the bioactivity of two glucoraphanin hydrolysis products found in broccoli, sulforaphane and sulforaphane nitrile

1 reference

12 December 2020

A prospective study of cruciferous vegetables and prostate cancer.

1 reference

12 December 2020

NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis

1 reference

12 December 2020

Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.

1 reference

12 December 2020

Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes

1 reference

12 December 2020

Inhibition of carcinogenesis by isothiocyanates

1 reference

12 December 2020

Characterisation of recombinant epithiospecifier protein and its over-expression in Arabidopsis thaliana

1 reference

12 December 2020

Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates

1 reference

12 December 2020

Linking metabolic QTLs with network and cis-eQTLs controlling biosynthetic pathways

1 reference

12 December 2020

Inhibition of nuclear translocation of nuclear factor-{kappa}B contributes to 3,3'-diindolylmethane-induced apoptosis in breast cancer cells.

1 reference

12 December 2020

Structure elucidation of acid reaction products of indole-3-carbinol: detection in vivo and enzyme induction in vitro

1 reference

12 December 2020

Cellular accumulation of dietary anticarcinogenic isothiocyanates is followed by transporter-mediated export as dithiocarbamates

1 reference

12 December 2020

Chemical structures of inducers of nicotinamide quinone oxidoreductase 1 (NQO1).

1 reference

12 December 2020

Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

1 reference

12 December 2020

Purification and characterisation of epithiospecifier protein from Brassica napus: enzymic intramolecular sulphur addition within alkenyl thiohydroximates derived from alkenyl glucosinolate hydrolysis

1 reference

12 December 2020

In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat.

1 reference

12 December 2020

Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms.

1 reference

12 December 2020

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

1 reference

12 December 2020

Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic Phase 2 enzymes.

1 reference

12 December 2020

Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice

1 reference

12 December 2020

Sulforaphane modulates cell cycle and apoptosis in transformed and non-transformed human T lymphocytes

1 reference

12 December 2020

Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation

1 reference

12 December 2020

A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.

1 reference

12 December 2020

Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter

1 reference

12 December 2020

Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines

1 reference

12 December 2020

Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention?

1 reference

12 December 2020

Histone deacetylases specifically down-regulate p53-dependent gene activation

1 reference

12 December 2020

Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver

1 reference

12 December 2020

Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence

1 reference

12 December 2020

Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap n collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2)

1 reference

12 December 2020

Glutathione transferases

1 reference

12 December 2020

The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes

1 reference

12 December 2020

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

1 reference

12 December 2020

Content of glucosinolates in cruciferous vegetables grown at the same site for two years under different climatic conditions

1 reference

12 December 2020

Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner

1 reference

12 December 2020

Caspase-dependent apoptosis induction by phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent, is mediated by Bak and Bax.

1 reference

12 December 2020

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase

1 reference

12 December 2020

Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IkappaB kinase/nuclear factor-kappaB pathway

1 reference

12 December 2020

Analysis of glucosinolates, isothiocyanates, and amine degradation products in vegetable extracts and blood plasma by LC-MS/MS.

1 reference

12 December 2020

Gene expression profiles of I3C- and DIM-treated PC3 human prostate cancer cells determined by cDNA microarray analysis.

1 reference

12 December 2020

Indole-3-carbinol (I3C) inhibits cyclin-dependent kinase-2 function in human breast cancer cells by regulating the size distribution, associated cyclin E forms, and subcellular localization of the CDK2 protein complex.

1 reference

12 December 2020

Non-nutritive bioactive constituents of plants: dietary sources and health benefits of glucosinolates.

1 reference

12 December 2020

Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cells.

1 reference

12 December 2020

Phenethyl isothiocyanate-induced apoptosis in p53-deficient PC-3 human prostate cancer cell line is mediated by extracellular signal-regulated kinases.

1 reference

12 December 2020

The gene controlling the quantitative trait locus EPITHIOSPECIFIER MODIFIER1 alters glucosinolate hydrolysis and insect resistance in Arabidopsis

1 reference

12 December 2020

The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells.

1 reference

12 December 2020

Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

1 reference

12 December 2020

Indole-3-carbinol inhibition of androgen receptor expression and downregulation of androgen responsiveness in human prostate cancer cells

1 reference

12 December 2020

Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species.

1 reference

12 December 2020

Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells.

1 reference

12 December 2020

Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival

1 reference

12 December 2020

Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

1 reference

12 December 2020

Selected isothiocyanates rapidly induce growth inhibition of cancer cells.

1 reference

12 December 2020

Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin

1 reference

12 December 2020

Glucosinolates: bioavailability and importance to health

1 reference

12 December 2020

Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells

1 reference

12 December 2020

Indole-3-carbinol is a negative regulator of estrogen

1 reference

12 December 2020

A critical review of the bioavailability of glucosinolates and related compounds

1 reference

12 December 2020

A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure

1 reference

12 December 2020

The Arabidopsis epithiospecifier protein promotes the hydrolysis of glucosinolates to nitriles and influences Trichoplusia ni herbivory

1 reference

12 December 2020

Studies on the mechanism of the inhibition of human leukaemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro.

1 reference

12 December 2020

ESP and ESM1 mediate indol-3-acetonitrile production from indol-3-ylmethyl glucosinolate in Arabidopsis.

1 reference

12 December 2020

Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.

1 reference

12 December 2020

Brassica vegetables and cancer prevention. Epidemiology and mechanisms.

1 reference

12 December 2020

Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation

1 reference

12 December 2020

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

1 reference

12 December 2020

Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts

1 reference

12 December 2020

Chemical and biological properties of indole glucosinolates (glucobrassicins): a review

1 reference

12 December 2020

Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China.

1 reference

12 December 2020

Involvement of glutathione metabolism in the cytotoxicity of the phenethyl isothiocyanate and its cysteine conjugate to human leukaemia cells in vitro

1 reference

12 December 2020

A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway

1 reference

12 December 2020

2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells.

1 reference

12 December 2020

Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.

1 reference

12 December 2020

Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable

1 reference

12 December 2020

Structure-activity relationships of isothiocyanates as mechanism-based inhibitors of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice.

1 reference

12 December 2020

Cell cycle arrest, apoptosis induction and inhibition of nuclear factor kappa B activation in anti-proliferative activity of benzyl isothiocyanate against human pancreatic cancer cells

1 reference

12 December 2020

Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries

1 reference

12 December 2020

Redox regulation of glutathione S-transferase induction by benzyl isothiocyanate: correlation of enzyme induction with the formation of reactive oxygen intermediates

1 reference

12 December 2020

The cruciferous nitrile crambene has bioactivity similar to sulforaphane when administered to Fischer 344 rats but is far less potent in cell culture.

1 reference

12 December 2020

Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors

1 reference

12 December 2020

Dual action of sulforaphane in the regulation of thioredoxin reductase and thioredoxin in human HepG2 and Caco-2 cells

1 reference

12 December 2020

Fate of indole-3-carbinol in cultured human breast tumor cells

1 reference

12 December 2020

Dietary isothiocyanates inhibit the growth of human bladder carcinoma cells.

1 reference

12 December 2020

Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: direct cross-talk between phase I and II drug-metabolizing enzymes

1 reference

12 December 2020

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

1 reference

12 December 2020

Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice.

1 reference

12 December 2020

The methionine chain elongation pathway in the biosynthesis of glucosinolates in Eruca sativa (Brassicaceae)

1 reference

12 December 2020

Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype

1 reference

12 December 2020

Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization

1 reference

12 December 2020

The cruciferous nitrile, crambene, induces rat hepatic and pancreatic glutathione S-transferases.

1 reference

12 December 2020

Heating decreases epithiospecifier protein activity and increases sulforaphane formation in broccoli.

1 reference

12 December 2020

Glucosinolates and their breakdown products in food and food plants

1 reference

12 December 2020

Indole-3-carbinol activates the cyclin-dependent kinase inhibitor p15(INK4b) gene

1 reference

12 December 2020

Preparation and biological activity of four epiprogoitrin myrosinase-derived products

1 reference

12 December 2020

The enzymic and chemically induced decomposition of glucosinolates

1 reference

12 December 2020

Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells.

1 reference

12 December 2020

Ascorbigen and other indole-derived compounds from Brassica vegetables and their analogs as anticarcinogenic and immunomodulating agents

1 reference

12 December 2020

Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein.

1 reference

12 December 2020

ERRbeta: a potent inhibitor of Nrf2 transcriptional activity

1 reference

12 December 2020

Inhibition and inactivation of human cytochrome P450 isoforms by phenethyl isothiocyanate

1 reference

12 December 2020

Modification of aflatoxin B1 biotransformation in vitro and DNA binding in vivo by dietary broccoli in rats

1 reference

12 December 2020

Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells

1 reference

12 December 2020

Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6 and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling.

1 reference

12 December 2020

A glutathione S-transferase inducer from papaya: rapid screening, identification and structure-activity relationship of isothiocyanates

1 reference

12 December 2020

Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates

1 reference

12 December 2020

Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C.

1 reference

12 December 2020

Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex

1 reference

12 December 2020

Gene expression of detoxifying enzymes in AhR and Nrf2 compound null mutant mouse

1 reference

12 December 2020

Epithiospecifier protein from broccoli (Brassica oleracea L. ssp. italica) inhibits formation of the anticancer agent sulforaphane

1 reference

12 December 2020

Diindolylmethane alters gene expression in human keratinocytes in vitro

1 reference

12 December 2020

Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer

1 reference

12 December 2020

The chemical diversity and distribution of glucosinolates and isothiocyanates among plants

1 reference

12 December 2020

Allyl-isothiocyanate causes mitotic block, loss of cell adhesion and disrupted cytoskeletal structure in HT29 cells.

1 reference

12 December 2020

Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse.

1 reference

12 December 2020

Metabolism of sinigrin (2-propenyl glucosinolate) by the human colonic microflora in a dynamic in vitro large-intestinal model.

1 reference

12 December 2020

Formation of allyl isothiocyanate from sinigrin in the digestive tract of rats monoassociated with a human colonic strain of Bacteroides thetaiotaomicron

1 reference

12 December 2020

Signal transduction activated by the cancer chemopreventive isothiocyanates: cleavage of BID protein, tyrosine phosphorylation and activation of JNK

1 reference

12 December 2020

Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.

1 reference

12 December 2020

The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance

1 reference

12 December 2020

Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane.

1 reference

12 December 2020

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

1 reference

12 December 2020

Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane

1 reference

12 December 2020

Inactivation of akt and NF-kappaB play important roles during indole-3-carbinol-induced apoptosis in breast cancer cells

1 reference

12 December 2020

Variation of glucosinolates in vegetable crops of Brassica oleracea

1 reference

12 December 2020

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

1 reference

12 December 2020

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

1 reference

12 December 2020

Metabolic engineering of p-hydroxybenzylglucosinolate in Arabidopsis by expression of the cyanogenic CYP79A1 from Sorghum bicolor

1 reference

12 December 2020

Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates

1 reference

12 December 2020

The BCL-2 protein family: opposing activities that mediate cell death

1 reference

12 December 2020

Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells.

1 reference

12 December 2020