Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex (Q24657851)

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4 January 2020

title

Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex (English)

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4 January 2020

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1

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4 January 2020

author name string

Ty E Adams

2

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4 January 2020

Jyoti Nangalia

3

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4 January 2020

Charles T Esmon

4

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4 January 2020

James A Huntington

5

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4 January 2020

language of work or name

English

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publication date

24 March 2008

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Proceedings of the National Academy of Sciences of the United States of America

4 January 2020

published in

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4 January 2020

volume

105

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4 January 2020

issue

12

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4 January 2020

page(s)

4661-4666

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Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism

4 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

Structure of a serpin-protease complex shows inhibition by deformation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

Elucidating the structural chemistry of glycosaminoglycan recognition by protein C inhibitor

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

Structure of native protein C inhibitor provides insight into its multiple functions

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

The molecular basis of thrombin allostery revealed by a 1.8 A structure of the "slow" form

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

Crystal structure of protein C inhibitor provides insights into hormone binding and heparin activation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

Likelihood-enhanced fast translation functions

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

Automated protein model building combined with iterative structure refinement

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

7 April 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

7 April 2017

https://api.crossref.org/works/10.1073/PNAS.0711055105

On the size of the active site in proteases. I. Papain

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

Serpin structure, mechanism, and function

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

Protein C inhibitor. Purification from human plasma and characterization

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

Deficiency of protein C inhibitor in combined factor V/VIII deficiency disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

Serpins in thrombosis, hemostasis and fibrinolysis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

Shape-shifting serpins--advantages of a mobile mechanism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

Mechanisms of glycosaminoglycan activation of the serpins in hemostasis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

Conformational changes in serpins: I. The native and cleaved conformations of alpha(1)-antitrypsin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

Contribution of basic residues of the D and H helices in heparin binding to protein C inhibitor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

Role of the H helix in heparin binding to protein C inhibitor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

A comparison of three heparin-binding serine proteinase inhibitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

Thrombomodulin enhances the reactivity of thrombin with protein C inhibitor by providing both a binding site for the serpin and allosterically modulating the activity of thrombin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

Protein C inhibitor (plasminogen activator inhibitor-3) and the risk of venous thrombosis.

30 May 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0711055105

Activated protein C-protein C inhibitor complex: a new biological marker for aortic aneurysms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0711055105

Conformational changes in thrombin when complexed by serpins

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0711055105

Crystal structure of thrombin bound to heparin

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0711055105

Protein C inhibitor, a serpin with functions in- and outside vascular biology.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290767

Mechanism by which exosites promote the inhibition of blood coagulation proteases by heparin-activated antithrombin

28 November 2018

1 reference

12 December 2020

Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101

1 reference

12 December 2020

Protein C Inhibitor Is a Potent Inhibitor of the Thrombin-Thrombomodulin Complex

1 reference

12 December 2020

Plasma protein C inhibitor is elevated in survivors of myocardial infarction

1 reference

12 December 2020

Inactivation of thrombin by antithrombin is accompanied by inactivation of regulatory exosite I

1 reference

12 December 2020

Heparin binding of protein-C inhibitor--analysis of the effect of heparin on the interaction of protein-C inhibitor with tissue kallikrein

1 reference

12 December 2020

Essential thrombin residues for inhibition by protein C inhibitor with the cofactors heparin and thrombomodulin

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0711055105

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18362344%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

0 references

1 reference

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4 January 2020

PubMed publication ID

18362344

1 reference