Structure of native protein C inhibitor provides insight into its multiple functions (Q27643980)

2

0 references

Margareta Kjellberg

3

0 references

Johan Stenflo

4

0 references

James A Huntington

Journal of Biological Chemistry

5

0 references

language of work or name

English

0 references

publication date

4 May 2007

0 references

published in

0 references

volume

282

0 references

issue

18

0 references

page(s)

13759-68

0 references

cites work

Protein C inhibitor (PCI)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Serpin structure, mechanism, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Deficiency of protein C inhibitor in combined factor V/VIII deficiency disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Protein C inhibitor (PCI) and heparin cofactor II (HCII): possible alternative roles of these heparin-binding serpins outside the hemostatic system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Structure of a serpin-protease complex shows inhibition by deformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

On the size of the active site in proteases. I. Papain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Active site distortion is sufficient for proteinase inhibition by serpins: structure of the covalent complex of alpha1-proteinase inhibitor with porcine pancreatic elastase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Elucidating the structural chemistry of glycosaminoglycan recognition by protein C inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Contribution of basic residues of the D and H helices in heparin binding to protein C inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Mechanisms of glycosaminoglycan activation of the serpins in hemostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Biological implications of a 3 A structure of dimeric antithrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

The anticoagulant activation of antithrombin by heparin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

The heparin binding properties of heparin cofactor II suggest an antithrombin-like activation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Hormone binding globulins undergo serpin conformational change in inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Binding of retinoic acid by the inhibitory serpin protein C inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Crystal structure of protein C inhibitor provides insights into hormone binding and heparin activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Likelihood-enhanced fast translation functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Refinement of macromolecular structures by the maximum-likelihood method

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Raster3D Version 2.0. A program for photorealistic molecular graphics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Different affinities of glycosaminoglycan oligosaccharides for monomeric and dimeric interleukin-8: a model for chemokine regulation at inflammatory sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Critical role of the linker region between helix D and strand 2A in heparin activation of antithrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Characterization of recombinant human protein C inhibitor expressed in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Structural mechanism for the carriage and release of thyroxine in the blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Wild-type alpha 1-antitrypsin is in the canonical inhibitory conformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Antithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Allosteric activation of antithrombin is independent of charge neutralization or reversal in the heparin binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Basic residues in the 37-loop of activated protein C modulate inhibition by protein C inhibitor but not by alpha(1)-antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Structural and energetic characteristics of the heparin-binding site in antithrombotic protein C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Contribution of basic residues of the 70-80-loop to heparin binding and anticoagulant function of activated protein C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Protein C inhibitor secreted from activated platelets efficiently inhibits activated protein C on phosphatidylethanolamine of platelet membrane and microvesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200

Role of each Asn-linked glycan in the anticoagulant activity of human protein C inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701074200