Specificity in Ras and Rap signaling (Q24657954)

Journal of Biological Chemistry

Europe PubMed Central

title

Specificity in Ras and Rap signaling (English)

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Judith H Raaijmakers

1

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Johannes L Bos

series ordinal

2

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language of work or name

English

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publication date

24 April 2009

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published in

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volume

284

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issue

17

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page(s)

10995-9

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cites work

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Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1

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The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes

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Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion

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MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion

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The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane

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RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1

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Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

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RA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activation

7 April 2017

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Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras

7 April 2017

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Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction

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The structural basis of the activation of Ras by Sos

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Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22

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The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction

7 April 2017

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KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions

7 April 2017

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GEFs and GAPs: critical elements in the control of small G proteins

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RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation

7 April 2017

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RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion

7 April 2017

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Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon

7 April 2017

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Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation

7 April 2017

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A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase

7 April 2017

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Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling

7 April 2017

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Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

7 April 2017

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Characterization of interactions of adapter protein RAPL/Nore1B with RAP GTPases and their role in T cell migration

7 April 2017

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IQGAP1 binds Rap1 and modulates its activity

28 September 2017

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The Par polarity complex regulates Rap1- and chemokine-induced T cell polarization

28 September 2017

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ARAP3 is essential for formation of lamellipodia after growth factor stimulation

28 September 2017

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AF6 negatively regulates Rap1-induced cell adhesion

28 September 2017

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RA-RhoGAP, Rap-activated Rho GTPase-activating protein implicated in neurite outgrowth through Rho.

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Regulation of E-cadherin endocytosis by nectin through afadin, Rap1, and p120ctn

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Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors

28 September 2017

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Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking

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Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate

28 September 2017

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The role of Rap1 in integrin-mediated cell adhesion

28 September 2017

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Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

28 September 2017

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CalDAG-GEFIII activation of Ras, R-ras, and Rap1.

28 September 2017

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The Ras target AF-6 interacts with ZO-1 and serves as a peripheral component of tight junctions in epithelial cells

28 September 2017

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Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester

28 September 2017

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GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670103

Activation of the Rap GTPases in B Lymphocytes Modulates B Cell Antigen Receptor-induced Activation of Akt but Has No Effect on MAPK Activation

30 May 2018

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Regulation of epithelial wound closure and intercellular adhesion by interaction of AF6 with actin cytoskeleton.

21 January 2018

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Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.

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Protein kinase D1 and the beta 1 integrin cytoplasmic domain control beta 1 integrin function via regulation of Rap1 activation.

21 January 2018

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The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity

21 January 2018

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Epac signaling pathway involves STEF, a guanine nucleotide exchange factor for Rac, to regulate APP processing

21 January 2018

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Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development

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The RapGEF PDZ-GEF2 is required for maturation of cell-cell junctions

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12 December 2020

Recognizing and defining true Ras binding domains I: biochemical analysis

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12 December 2020

Common signaling pathway is used by the trans-interaction of Necl-5/Tage4/PVR/CD155 and nectin, and of nectin and nectin during the formation of cell-cell adhesion

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12 December 2020

Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes

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12 December 2020