Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta (Q24669877)

1

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Stephen J Orena

2

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Kristina Rafidi

3

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Anthony J Torchia

4

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Jeffrey L Stock

5

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Audrey L Hildebrandt

6

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Timothy Coskran

7

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Shawn C Black

8

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Dominique J Brees

9

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Joan R Wicks

10

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John D McNeish

11

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Kevin G Coleman

Journal of Clinical Investigation

12

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language of work or name

English

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publication date

July 2003

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published in

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volume

112

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page(s)

197-208

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issue

2

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cites work

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Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

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Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia

7 April 2017

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Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

7 April 2017

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7 April 2017

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Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1)

7 April 2017

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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

7 April 2017

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

7 April 2017

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Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

7 April 2017

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Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

7 April 2017

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Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance

28 September 2017

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Genetic analysis of insulin signaling in Drosophila

28 September 2017

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Distinct and overlapping functions of insulin and IGF-I receptors

28 September 2017

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Ten years of protein kinase B signalling: a hard Akt to follow

28 September 2017

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Inhibition of cAMP-response element-binding protein activity decreases protein kinase B/Akt expression in 3T3-L1 adipocytes and induces apoptosis.

28 September 2017

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High prevalence of type 2 diabetes in all ethnic groups, including Europeans, in a British inner city: relative poverty, history, inactivity, or 21st century Europe?

28 September 2017

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Understanding the pathogenesis and treatment of insulin resistance and type 2 diabetes mellitus: what can we learn from transgenic and knockout mice?

28 September 2017

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28 September 2017

Lipoatrophy revisited

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Islet growth and development in the adult

28 September 2017

1 reference

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Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

28 September 2017

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Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.

28 September 2017

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Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site.

28 September 2017

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Deconstructing type 2 diabetes

28 September 2017

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Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

28 September 2017

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Glycogen synthase: a new activity ratio assay expressing a high sensitivity to the phosphorylation state

28 September 2017

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A new embryonic stem cell line from DBA/1lacJ mice allows genetic modification in a murine model of human inflammation

28 September 2017

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Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene.

28 September 2017

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Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1.

28 September 2017

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Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

30 May 2018

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Insulin-sensitive regulation of glucose transport and GLUT4 translocation in skeletal muscle of GLUT1 transgenic mice

30 May 2018

1 reference

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Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin

30 May 2018

1 reference

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Construction and characterization of a conditionally active version of the serine/threonine kinase Akt.

30 May 2018

1 reference

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PDK1, one of the missing links in insulin signal transduction?

30 May 2018

1 reference

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Expression of a constitutively activated form of protein kinase B (c-Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164287

Production of chimeras between embryonic stem cells and embryos.

30 May 2018

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The influence of genetic background on the expression of the obese (ob) gene in the mouse

30 May 2018

1 reference

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Height and glucose tolerance in adult subjects.

30 May 2018

1 reference

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Validation of a high-resolution X-ray computed tomography system to measure murine adipose tissue depot mass in situ and longitudinally.

30 May 2018

1 reference

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The association between components of adult height and Type II diabetes and insulin resistance: British Women's Heart and Health Study.

28 November 2018

1 reference

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Differential beta cell responses to hyperglycaemia and insulin resistance in two novel congenic strains of diabetes (FVB- Lepr (db)) and obese (DBA- Lep (ob)) mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164287

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164287

Intrauterine growth retardation leads to the development of type 2 diabetes in the rat.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164287

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164287

Women with a history of gestational diabetes of European and South Asian origin are shorter than women with normal glucose tolerance in pregnancy.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164287

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164287

Genetic modifiers of the insulin resistance phenotype in mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164287

Profiling of Zucker diabetic fatty rats in their progression to the overt diabetic state.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164287

Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

28 November 2018

1 reference

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Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

28 November 2018

1 reference

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Genomic analysis of the C57BL/Ks mouse strain

28 November 2018

1 reference

12 December 2020

Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles

1 reference

12 December 2020

Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue

1 reference

12 December 2020

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

1 reference

12 December 2020

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

1 reference

12 December 2020

Impaired beta-cell regeneration in perinatally malnourished rats: a study with STZ

1 reference

12 December 2020

Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

1 reference

Crossref

https://api.crossref.org/works/10.1172%2FJCI16885

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1172/JCI16885

1 reference

1292021

1292021

1 reference

1 reference

1 reference