Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex (Q24670129)

2

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K G Suresh Kumar

3

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Jason D Weber

4

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J Wade Harper

5

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Andres J P Klein-Szanto

6

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Anil Rustgi

7

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Serge Y Fuchs

8

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J Alan Diehl

The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance

9

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language of work or name

English

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publication date

3 November 2006

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published in

Molecular Cell

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volume

24

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issue

3

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page(s)

355-66

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cites work

1 reference

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Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase

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Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

7 April 2017

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Stable suppression of gene expression by RNAi in mammalian cells

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The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation

7 April 2017

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The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates

7 April 2017

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The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.

7 April 2017

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F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

7 April 2017

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Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase

7 April 2017

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SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

7 April 2017

1 reference

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Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase

7 April 2017

1 reference

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Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

7 April 2017

1 reference

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The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

7 April 2017

1 reference

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Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation

7 April 2017

1 reference

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

7 April 2017

1 reference

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Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

7 April 2017

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Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway

7 April 2017

1 reference

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Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

7 April 2017

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7 April 2017

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Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1.

7 April 2017

1 reference

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Assembly of an APC-Cdh1-substrate complex is stimulated by engagement of a destruction box.

28 September 2017

1 reference

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Antizyme targets cyclin D1 for degradation. A novel mechanism for cell growth repression

28 September 2017

1 reference

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An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1702390

Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation

28 September 2017

1 reference

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The anaphase-promoting complex: it's not just for mitosis any more.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1702390

RNA interference: the new somatic cell genetics?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1702390

p21(Cip1) Promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1702390

Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1702390

Cyclin D1 overexpression and p53 inactivation immortalize primary oral keratinocytes by a telomerase-independent mechanism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1702390

A splice variant of Skp2 is retained in the cytoplasm and fails to direct cyclin D1 ubiquitination in the uterine cancer cell line SK-UT.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1702390

How do small GTPase signal transduction pathways regulate cell cycle entry?

28 September 2017

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The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

28 September 2017

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Chromosome aberrations in B-cell chronic lymphocytic leukemia: reassessment based on molecular cytogenetic analysis

28 September 2017

1 reference

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Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1702390

A dominant-negative cyclin D1 mutant prevents nuclear import of cyclin-dependent kinase 4 (CDK4) and its phosphorylation by CDK-activating kinase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1702390

Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

28 September 2017

1 reference

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Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1702390

Wnt1 and MEK1 cooperate to promote cyclin D1 accumulation and cellular transformation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1702390

Cyclin-dependent regulation of G1 in mammalian fibroblasts.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1702390

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1702390

Alternate splicing produces a novel cyclin D1 transcript

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1702390

Mimicking phosphorylation of the small heat-shock protein alphaB-crystallin recruits the F-box protein FBX4 to nuclear SC35 speckles

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1702390

Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1702390

A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1702390

The cyclin D1 alternative transcripts [a] and [b] are expressed in normal and malignant lymphocytes and their relative levels are influenced by the polymorphism at codon 241

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17081987

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The small heat-shock protein alpha B-crystallin promotes FBX4-dependent ubiquitination

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17081987

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hyperproliferation and p53 status of lens epithelial cells derived from alphaB-crystallin knockout mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17081987

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2006.09.007

1 reference

1 reference

1 reference

PubMed publication ID

17081987

1 reference